Probiotics improve constipation in patients with Parkinson’s disease

This study investigated whether probiotics (PBs) improve constipation in patients with Parkinson's disease (PD). Researchers suggested that PBs treatment improves constipation in these patients.

PD is a chronic disease that affects the brain. These cells lose their ability to control body functions leaving patients with symptoms such as tremors and stiff muscles. Bowel obstruction and decreased bowel movements are also common. Laxative therapy is the most common treatment for these patients. However, this treatment is of limited effectiveness and leads to the loss of healthy gut bacteria. Therefore, treatment with PB might control bowel symptoms. PBs are live healthy bacteria that improve the movements of the bowel. However, some of these studies are of low quality and with no safety outcomes. 

This study included 72 patients with PD and constipation. These patients were assigned to receive PBs (34) or placebo (38) for four weeks. The main outcome measured was the change in bowel movements per week. Other outcomes such as a change in stool consistency, constipation severity, and quality of life were also measured. 

Bowel movements increased by 1 movement a week in the PB group and decreased by 0.3 movements a week in the placebo group.

Significant improvements were also seen in stool consistency and quality of life. In the PB group, 65.6% of patients reported satisfaction with the treatment. This was compared to 21.6% of patients in the placebo group.

One patient in the PB group stopped treatment due to lack of energy.

This study concluded that treatment with PBs improves constipation in patients with Parkinson’s disease.

This study included a short follow-up period. Further studies with extended follow-up time are necessary.