In a nutshell
This study investigated the association retinal changes (RC) and Parkinson's disease (PD) stage. Researchers suggested that retina (the light-sensitive tissue in the back of the eye) changes could be a predictive factor for mental symptoms in these patients.
Some background
Parkinson's disease (PD) affects brain cells. As these cells die the abilities controlled by them are lost. This causes movement symptoms such as tremors and mental symptoms such as depression.
The retina is a layer at the back of the eyeball that allows us to see. Retina changes can be assessed by spectral-domain optical coherence tomography (SDOC). This consists of a non-invasive imaging technology (like CT-Scan) for the eye. Prior studies have suggested that retina changes are associated with diseases of the brain. However, the association between these changes and PD remains unclear.
Methods & findings
This study included 74 patients recently diagnosed with PD and 53 without the disease. The retina changes were assessed by SDOC.
Patients in the PD group showed significant retina changes. This included a decreased thickness of the retina layer. These changes were associated with a change in brain structures caused by PD. Patients with PD and mental impairment had significant lower retina thickness compared to patients without mental impairment.
The bottom line
This study concluded that retina changes can be used to predict mental symptoms in patients with PD.
The fine print
This study included only patients in the early stages. Further studies, with patients with more severe PD, are needed.
Published By :
Scientific reports
Date :
Aug 14, 2019
