Is nocturia associated with an increased risk of mortality?

This study investigated the relationship between nocturia and the risk of all-cause mortality by analyzing multiple observational studies. The authors concluded that increased nocturia episodes contribute to all-cause mortality risk.

Recent research has recognized nocturia as more than a bothersome symptom of aging. Nocturia not only affects quality of life but also overall health. It is believed that repeated interruptions to sleep may worsen existing health conditions, however the link between nocturia, comorbidities and mortality remains unclear.

This study analyzed health records of 28,220 participants across seven studies. Of these, 19.3% of participants had nocturia. 16.6% of all participants died during the study follow-up period (5 to 17.1 years).

Compared to other participants, nocturia patients showed a 23% increase in the risk of all-cause mortality (death from any cause). Patients who experienced 2 or more voids (urinations) per night showed a 6% increased risk, compared to a 46% increase in risk among patients who reported 3 or more voids per night.

Gender and age influenced all-cause mortality risk associated with nocturia. Male patients had a 38% increased mortality risk, compared to a 32% increase in female patients. Patients aged 60 or less showed a 51% increase in mortality risk. Patients older than 60 showed a 33% increase in mortality risk.

The authors concluded that increased nocturia episodes contribute to all-cause mortality risk.

In this analysis, data about nocturia was collected from self-reported questionnaires. This limits the conclusions that may be drawn from these results. Also, normal participants may have developed nocturia during follow-up. This may lead to over- or underestimated mortality rates. Lastly, most of the studies in this analysis did not investigate the cause of death or the impact of specific disorders. More studies are needed to confirm these results and further determine the influence of nocturia on comorbidities and mortality risk.

Nocturia doesn’t have to be endured. Talk with your physician on how to maximize your health and quality of life.