In a nutshell
This study investigated factors that may affect live birth rates (LBR) in women with diminished ovarian reserve (DOR). They found that maternal age and embryo stage and number affected LBR in these women.
Some background
Female infertility can be caused by a condition called diminished ovarian reserve (DOR). Women with DOR may have fewer oocytes (eggs) in their ovaries. Other women may have poor quality oocytes. DOR affects approximately 10% of women seeking infertility treatment. DOR can also have a negative impact on fertility treatment. During controlled ovarian stimulation (COS), the response in patients with DOR can be poor. This makes it difficult to harvest eggs for assisted reproductive techniques (ART).
It is unclear what causes DOR. Some studies suggest maternal age or blood type may affect ovarian reserve. It is unknown if there are factors affecting live birth rates (LBR) in women with DOR undergoing ART.
Methods & findings
This study included the records of 1957 women with DOR. They underwent 2277 ART cycles. Information on the ART cycles and outcomes such as live birth rates were analyzed.
LBR was reduced by 74% in women aged 40 or over as compared to those of 30 or under. Embryo’s transferred at stage (day) 3 had a 53% increased chance of LBR. As compared to women who had only one embryo transferred, those with two or three embryos transferred had 2.53 times and 4.59 times higher chances for LBR.
The bottom line
The authors concluded that higher age and embryo stage and number affected LBR in women with DOR.
The fine print
This study was based on medical records. We do not have any information on the possible causes of DOR. This study analyzed fresh-embryo ART cycles. Therefore the results cannot be applied to frozen-embryo transfer.
What’s next?
If you have any concerns regarding fertility treatment, please consult with your physician.
Published By :
Archives of Gynecology and Obstetrics
Date :
Sep 19, 2018
