In a nutshell
This study investigated if there is a link between polycystic ovary syndrome (PCOS) and miscarriage due to genetic abnormalities.
They found that women with PCOS had a higher risk of miscarriage due to genetic abnormalities.
Some background
Polycystic ovary syndrome (PCOS) is a common condition in women. Patients with PCOS may not ovulate normally. This can lead to problems with fertility. Many women with PCOS undergo assisted reproductive techniques (ART). Controlled ovarian stimulation (COS) is used to stimulate the release of oocytes (eggs) from the ovaries. In vitro fertilization (IVF) is then performed. The success of IVF is lower in patients with PCOS. Some studies suggest that oocyte quality may be an issue.
One factor that might affect oocyte quality and IVF success is chromosomal (a part of the genetic information) abnormalities (CA). CA leads to approximately 50% of miscarriages in normal pregnancies. This is called chromosomally aberrant miscarriage (CAM). It is unclear if there is a higher risk of CAM in patients with PCOS undergoing ART.
Methods & findings
This study 328 women that experienced a miscarriage after ART. Miscarriage occurred in the first trimester. These patients were grouped as PCOS (119) or non-PCOS (209). A sample from the chorionic villi (blood supply) of the fetus was analyzed.
52.7% of samples were positive for CA. The CA was responsible for miscarriage in 91.3% of these pregnancies. The most common CA was an extra chromosome copy (trisomy). Monosomy (missing a chromosome) was also common. The risk of CA was higher in patients with PCOS. Further analysis showed PCOS increased the risk of CAM twofold.
The bottom line
The authors concluded that women with PCOS had a higher risk of miscarriage due to chromosome abnormalities.
The fine print
This study did not analyze male factors (sperm) that might influence CA. The mechanism involved in CA is not clear. More investigation is needed.
What’s next?
If you have any concerns regarding infertility and ART please consult with your physician.
Published By :
Fertility and Sterility
Date :
Mar 25, 2019
