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Posted by on Jun 29, 2015 in Infertility | 0 comments

In a nutshell

This study examined whether the 2010 World Health Organization (WHO) guidelines can effectively identify patients who will benefit from surgery to repair varicocele. 

Some background

Infertility, or the inability to conceive, affects 5-15% of couples worldwide. Swelling of the veins within the testes, known as varicocele, is a common cause of infertility in men. It is easily treated and surgical removal of the vein is known to improve the quality of semen and increase pregnancy rates. In 2010, the WHO announced new guidelines for diagnosing infertility. However, few studies have looked at the effect of the new guidelines on the diagnosis and treatment of infertile men. 

Methods & findings

A total of 206 men took part in this study. Here, the researchers examined the past medical records of men who had surgery to repair varicocele between 2004 and 2012. These men were advised to have surgery by their doctors because they had abnormal semen parameters according to the 1999 WHO guidelines, which were in place at the time. 
 
This study shows that if the same men were to be diagnosed in the present day, and according to the latest 2010 WHO guidelines, 55% of them would have been advised by their doctor not to have surgery. This is because their semen parameters would be seen as “normal” under the new guidelines. Strikingly though, more than half of these “normal” men actually benefitted from the surgery and showed either improved sperm counts (47%) or improved motility (20%) after surgery. 

The bottom line

The authors conclude that a large improvement in semen parameters can be found in patients whose semen results are normal according to the current guidelines, but would have been abnormal according to the previous guidelines. Therefore, under the new guidelines many men may be refused potentially beneficial varicocele repair surgery. 

The fine print

While sperm quality was improved, pregnancy rates after surgery were not studied.

What’s next?

If you are considering treatment for varicocele, please discuss any concerns with your doctor.  
Published By :

Urology

Date :

Apr 01, 2015

Original Title :

Usefulness of 2010 world health organization reference values for determining indications for varicocelectomy.

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