In a nutshell
This study investigated the best dose of follitropin delta (FD; Rekovelle) in women undergoing controlled ovarian stimulation (COS).
They found that 10 micrograms of FD has similar effectiveness to the standard dose of follitropin alpha (FA; Gonal-F).
Some background
Assisted reproductive technology (ART) is used to treat infertility. Controlled ovarian stimulation (COS) is usually the first step in ART. It is used to stimulate the release of mature oocytes (eggs) from the ovaries. There are many different ways to induce COS. Gonadotropin-releasing hormone (GnRH) is important in ovulation. Drugs that block or stimulate GnRH can be used in COS.
Follicle-stimulating hormone (FSH) is a natural hormone. It blocks the activity of GnRH. Follitropin alpha (FA) is a synthetic form of FSH. It has been used in COS for many years. A new synthetic form of FSH has recently been developed. It is called follitropin delta (FD). Even though FA and FD are both synthetic forms of FSH, they are not exactly the same. The potency or strength may differ. It is unclear what dose of FD produces the same effect as a standard dose (150 IU/day) of FA.
Methods & findings
This study included 1591 patients undergoing ART. Patients were randomly assigned to one of 6 groups. 5 groups received a dose of FD. The sixth group received a standard dose of FA. This was 11 micrograms or 150 IU per day. The number of oocytes retrieved (NOOR) was compared between groups.
10 or 10.3 micrograms of FD per day was associated with the same NOOR as standard FA. In patients with normal or high ovarian reserve doses of 9.3 or 9.7 micrograms FD were similarly effective as FA 150 IU per day.
The bottom line
The authors concluded that 10 micrograms FD per day has similar effects to the standard dose of FA for COS.
The fine print
This study did not look at the safety profile of FD. This study was funded by Ferring Pharmaceuticals, the manufacturer of FD.
What’s next?
If you have any concerns regarding infertility please consult with your physician.
Published By :
Reproductive BioMedicine Online
Date :
Oct 01, 2020
