In a nutshell
This study explored the impact of endometrial thickness on pregnancy rates in patients undergoing in vitro fertilization (IVF). The study concluded that thin endometrial thickness adversely affects ongoing pregnancy rates.
Some background
Successful pregnancy rates vary widely among couples undergoing in-vitro fertilization (IVF). Studies into factors which may improve the chances of successful treatment are ongoing. Endometrial thickness (the thickness of the internal layer lining the uterus) has been suggested to play an important role in IVF success. This study examined the association between endometrial thickness during IVF and pregnancy rates.
Methods & findings
10,046 patients undergoing first ever IVF cycle were included in this study. Endometrial thickness was assessed during ovulation (using fertility drugs to induce and control egg growth and release). Thin endometrial thickness was considered less than 7mm, medium thickness was considered 8-13mm, and a thick endometrium was that greater than 14mm.
Results showed higher pregnancy rates with thicker endometrial thickness. This was true regardless of the response to ovulation drugs (the number of developed eggs retrieved during IVF).
Among women with a thick endometrium, pregnancy rates were 51 to 63%, depending on ovulation. Among women with medium endometrial thickness, pregnancy rates were 44 to 55%, depending on ovulation. Among women with a thin endometrium, pregnancy rates were 28 to 32%, depending on ovulation.
The bottom line
The study concluded that endometrial thickness significantly effects IVF outcomes.
Published By :
PLOS ONE
Date :
Dec 30, 2015
