Endocannabinoids and fertility

This article reviewed the role of endocannabinoids (eCBs) as potential biomarkers of human reproduction.

Biomarkers refer to biological molecules used as indicators of normal or abnormal processes in the human body. Successful biomarker profiling could help predict the reproductive potential of couples, as well as determine which couples might benefit most from assisted reproductive technologies. Endocannabinoids, naturally produced signaling molecules which control many of the body's functions, have been suggested as potential markers of human fertility in several recent studies.

This review analyzed recent research regarding the role of endocannabinoids in human reproduction. A recent study has demonstrated that anandamide (a type of endocannabinoid) may be crucial in the development of mature eggs in healthy women. High anandamide concentrations in the fluid surrounding the developing eggs were found to predict mature egg formation in 77% of cases. Other reviewed studies have suggested that high anandamide levels at the time of ovulation and implantation are essential for a successful pregnancy among otherwise healthy women.
Studies evaluating the role of endocannabinoids in men showed that high anandamide levels in men are associated with decreased sperm motility.

This review concluded that endocannabinoids may act as potential markers of fertility, and further research into the association between endocannabinoids and fertility is warranted.