Does obesity influence birth rates after IVF?

This study investigated if obesity is associated with fertility outcomes after in vitro fertilization (IVF).

They found that obesity was associated with a lower live birth rate (LBR) after IVF.

The rate of obesity is increasing rapidly worldwide. Obesity can have a negative impact on overall health. It can also have a negative effect on fertility. Some studies also suggest obesity can affect fertility outcomes. This may be true also for patients undergoing assisted reproduction techniques (ART). 

One of the first steps in ART is in vitro fertilization (IVF). Obesity has been linked to reduced oocyte (egg) recovery and miscarriage. Some studies also suggest that obesity affects live birth rate (LBR) after IVF. The data supporting this is conflicting. An analysis of available data is needed.

This study analyzed 21 reports from clinical trials. Obese was classified as a body mass index (BMI) greater than 30kg/m². The women in these trials were undergoing IVF as part of different trial designs. The authors compared LBR between obese and non-obese patients. 

Overall, the LBR was 15% lower in obese patients after IVF. This was further reduced in obese patients with polycystic ovarian syndrome (PCOS; a condition associated with infertility where the patients can have many cysts on their ovaries and/or high testosterone levels). The LBR was reduced by 6% compared to non-obese patients with PCOS. The LBR was similar in obese and non-obese patients without PCOS. There was also a 6% reduction in LBR for overweight patients (BMI 25.0-29.9kg/m²).

The authors concluded that obesity was associated with lower LBR after IVF.

Some important patient information was not available. IVF protocols can vary. Both of these factors could have an impact on the study findings. More investigation is needed. 

If you have any concerns regarding fertility problems, please consult with your doctor.