In a nutshell
This study examined whether high blood glucose levels can alter the function of arteries. The authors concluded that type 2 diabetes patients, particularly those with decreased kidney function, have higher arterial stiffness after experiencing high blood glucose levels.
Some background
Patients with type 2 diabetes (T2D) have a higher risk of developing cardiovascular disease. Cardiovascular disease (CVD) is the narrowing or blockage of blood vessels and arteries, and can lead to heart failure or stroke. Narrowing of arteries is due to a build-up of fats (such as cholesterol) on the walls of arteries. Narrowing can increase the stiffness of the arteries, which makes it harder for blood to flow. It can also lead to changes in the cells lining the blood vessels.
Postprandial blood glucose levels (BGL) are the sugar levels in the blood after eating a meal. High postprandial BGL increases the risk of CVD. It is thought that high postprandial BGL may reduce the function of the arteries, therefore increasing the risk of CVD.
Methods & findings
This study aimed to determine whether postprandial BGL affects arterial function. This study involved 71 participants divided into 2 groups. 24 participants had T2D, 22 participants had T2D and albuminuria (protein in the urine due to kidney disease) and 25 participants did not have T2D.
All participants took part in two sessions. In one session, participants experienced high postprandial BGL after eating breakfast by not taking any insulin. In the other session, insulin was administered as normal. Stiffness and function of the arteries were measured 30 minutes prior to breakfast and up to 240 minutes after breakfast.
After experiencing high postprandial BGL, arterial stiffness was higher in T2D patients who had albuminuria compared to non-diabetic individuals. In comparison to non-diabetic individuals, protein levels that indicate inflammation were higher in T2D patients.
The bottom line
This study concluded that arterial stiffness is higher in T2D patients with albuminuria after experiencing high BGL.
The fine print
The participants in this study were all men. It is not clear whether the results would be similar in women.
What’s next?
Consult your physician regarding the importance of reducing postprandial BGL to prevent arterial stiffness.
Published By :
The Journal of clinical endocrinology and metabolism
Date :
Jan 05, 2016
