In a nutshell
The aim of this study was to examine the relationship between levels of blood magnesium and phosphate and diabetic nerve disease. The main finding of the study was that low levels of phosphate and magnesium in the blood were associated with diabetic nerve disease.
Some background
Patients with diabetes can develop diabetic peripheral neuropathy (DPN). DPN is when continuously high blood glucose damages the nerves in the hands, legs, and feet. It can lead to numbness, tingling, and pain. Due to the loss of feeling in the feet, foot ulcers may develop from cuts and sores. Diabetic foot ulcers are very difficult to heal and may result in infection and/or amputation. However, the underlying process of DPN is poorly understood.
Phosphate and magnesium are important substances in the energy-making process. Studies have shown that magnesium and phosphate are associated with other diabetic complications such as diabetic eye, kidney, and heart disease. It is unknown if magnesium and phosphate are associated with DPN.
Methods & findings
This study included the records of 254 patients with type 2 diabetes (T2D). Nerve function was evaluated by nerve conduction studies. 37.4% of patients were diagnosed with DPN.
Both magnesium and phosphate levels were significantly lower in patients with DPN. In patients with low phosphate levels, 42.68% had DPN compared to 26.74% of patients with high phosphate levels. Similarly, in patients with low magnesium, 46.99% had DPN compared to 26.74% of those who had high magnesium levels.
The bottom line
The authors concluded that low levels of magnesium and phosphate are associated with DPN.
The fine print
This study was based on medical records. Further prospective studies are needed for more conclusive results.
Published By :
Diabetes Research and Clinical Practice
Date :
Sep 28, 2018
