In a nutshell
This study investigated the associations of weight loss with bone mineral density and bone turnover in overweight postmenopausal breast cancer survivors. The study concluded that weight loss did not have a negative effect on bone health.
Some background
Chemotherapy may cause some patients to go through menopause by disrupting female hormones (such as estrogen). Menopause and a decrease in female hormones are associated with increased bone loss. Some cancer treatments are also known to decrease bone mineral density (BMD; the amount of calcium in the bones).
The effect of weight loss on BMD and bone turnover (normal process of bone being broken down and rebuilt) in postmenopausal breast cancer survivors is not well understood. This needs to be investigated as current guidelines recommend weight loss in obese cancer survivors.
Methods & findings
The current study investigated the impact of weight loss on BMD and bone turnover in overweight postmenopausal breast cancer survivors. 81 women were included in this study. All participants had been diagnosed with early-stage (stages 1-3a) breast cancer. Participants were enrolled in an exercise and nutrition program for weight loss. BMD and markers of bone turnover were measured at the start of the program and after 12 months.
Average weight had decreased by 2.3% after 12 months. There were significant decreases in markers of bone turnover. There were no significant changes in BMD.
The bottom line
The study concluded that weight loss over 12 months among postmenopausal, overweight/obese women with early-stage breast cancer does not appear to have a damaging effect on bone health, and could even be beneficial.
The fine print
These findings need to be confirmed in women who undergo a higher degree of weight loss.
Published By :
Breast Cancer Research and Treatment
Date :
Jul 15, 2015
