Evaluating the association of physical activity and sedentary behavior with fatigue, pain, and depressive symptoms among breast cancer survivors.

This study examined the association of physical activity (PA) and sedentary time (ST) with pain, fatigue, and depressive symptoms over time among survivors of breast cancer (BC). The data showed that lower ST and higher PA is associated with lower depressive symptoms in long-term survivors of BC.

BC is one of the most common forms of cancer in women. Fatigue, pain, and depressive symptoms are the most common long-term side effects after BC treatment. These interfere with the physical and psychological functioning and the quality of life of the patients.

Physical activity (PA) is important for a healthy lifestyle. PA is recommended as a safe and effective strategy to prevent and reduce symptoms of pain, fatigue, and depression. Sedentary behavior (SB) is associated with reduced health. Sedentary time (ST) describes low or absent PA and an increased period of time resting in a sitting or reclined position. ST has been associated with poorer quality of life, decreased wellbeing, and increased fatigue duration in patients of BC. However, the association of moderate-to-vigorous PA (MVPA) and ST with pain, fatigue, and depressive symptoms over time among breast cancer survivors is still unclear.

This study involved 199 long-term survivors of BC. All patients reported symptoms of pain, fatigue, and depression. Patients' MVPA and ST were measured with a device that detects acceleration or movement.

Higher levels of MVPA were associated with lower scores of depressive symptoms. Higher levels of ST were associated with higher scores of depressive symptoms.

Higher levels of ST were associated with increased pain levels over time. No significant association was found for MVPA with pain over time. Also, MVPA and ST were not associated to fatigue.

This study concluded that lower ST and higher MVPA are associated with lower depressive symptoms in long-term survivors of BC.

This trial was based upon self-reported (subjective) questionnaires for depressive symptoms, pain, and fatigue. This might affect the conclusions.