In a nutshell
This study examined the association between cardiovascular disease (CVD) and the presence of urinary symptoms. Researchers reported a significant increase in the 10-year CVD risk among men with severe urinary symptoms, after controlling for other risk factors.
Some background
The occurrence and symptoms of benign prostatic hyperplasia (BPH) generally advance with age. There is increasing evidence to suggest that metabolic factors are also important in the development and progression of BPH. Some of these include high body mass index (excess weight according to height), diabetes, high blood pressure, and high cholesterol levels. Such metabolic factors are known to increase the risk of cardiovascular disease (CVD; disease involving the heart and blood vessels). If left untreated, CVD can lead to stroke or a heart attack. Whether there is a link between BPH symptoms and CVD risk has not been fully studied.
Methods & findings
The aim of this study was to examine the link between CVD and the presence of urinary symptoms.
2,773 men from the general population were included in this study. The men were recruited while undergoing a voluntary health check at a health promotion center. Questionnaires recorded current symptoms and a medical history. Current urinary symptoms were classified as either mild, moderate, or severe. The predicted CVD risk at 10 years was defined as low (less than 10% risk at 10 years), intermediate (between 10 and 20%), and high (more than 20%).
The risk of CVD was significantly higher among men with a high body mass index, high blood pressure, diabetes, and those men who smoke cigarettes.
The presence of urinary symptoms significantly increased the risk of CVD. After adjusting for body mass index, prostate size and PSA levels, only men with severe urinary symptoms had a significant association with intermediate-high CVD risk. PSA (prostate specific antigen) is a protein elevated in the blood that indicates prostate growth. Overall, the predicted risk of intermediate-high CVD at 10 years was nearly 3 times higher in men with severe urinary symptoms compared to men with normal urinary function.
The bottom line
Researchers concluded that the presence of severe urinary symptoms is closely associated with future CVD risk.
The fine print
The men included in this study were not necessarily diagnosed with BPH. They may have had urinary symptoms due to other causes.
What’s next?
Discuss your risk factors for cardiovascular disease with your doctor.
Published By :
Neurourology and urodynamics
Date :
Jun 13, 2017
