Posted by on Aug 25, 2015 in Blog | 1 comment

Recent stories from the  Sepsis Alliance website are alarming.  People are healthy one day, feel crummy the next, then either die, or spend a long time in ICUs to survive with “life changing challenges.” For example, Elden Bailey (age 47) told his sister one Friday that he “didn’t feel too good.” Two days later, he was admitted to ICU and died 7 days later. Sepsis Alliance’s founder, Carl Flatley, lost his daughter to sepsis shortly after hemorrhoid surgery in 2002. Erin’s story involves trips to the ER where: her elevated white blood count went unheeded; prescribed antibiotics were not administered; severe shaking and racing heartbeat went unnoticed. How could this happen in a time of antibiotics and IVs?  Sepsis is complicated and treatment is time-sensitive.  A recent article in The Lancet stated, “Despite…hundreds of clinical trials…tens of thousands of patients, and…hundreds of millions of dollars, not one…novel drug has come to…market and…[been] incorporated into routine clinical practice.”

Sepsis Awareness Matters

Sepsis has been recognized for thousands of years. Hippocrates named sepsis.  Unfortunately, most people still don’t know what sepsis is. The common name, “blood poisoning,” adds confusion. Anything from appendicitis to a scraped knee can lead to sepsis. This is because any infectious organism can start a systemic inflammatory response syndrome (SIRS). Toxins produced by the foreign organism cause white blood cells to release cytokines which cause blood vessels to dilate, releasing fluids which causes swelling.  Normally,  this reaction is limited.  With sepsis, the response is systemic.  Blood pressure decreases. Blood clots in organs, impairing blood flow to organs. The effect cascades to damage tissue until organs fail.  Death follows.

Sepsis Stages

Sepsis is diagnosed by symptoms, not by the organism that triggered it.  The stages are mild, severe and septic shock.  Diagnosis requires two of these symptoms:
• Temperature above 101 or below 96.8 • Heart rate higher than 90 beats a minute • Respiration higher than 20 breaths a minute • Probable or confirmed infection
Severe sepsis occurs when an organ begins to fail. If you have one of these symptoms (along with two from above) you could have severe sepsis.
• Significantly decreased urine output • Abrupt change in mental status • Decrease in platelet count • Difficulty breathing • Abnormal heart pumping • Abdominal pain
Septic shock occurs with the above symptoms and low blood pressure.

No Specific Treatment

Treatment is antibiotics, surgery excising the infected area and IV fluids. Even so, the risk of death from sepsis is 15%; upon reaching septic shock, the risk of death is 40% or more. An  estimated 31 million cases of sepsis, 24 million cases of severe sepsis and around 6 million deaths occur each year worldwide. Sepsis strikes 10% of US hospital patients.

Recognizing What Is Sepsis

This anagram will help you recognize sepsis. “Shivering, fever or very cold” “Extreme pain or general discomfort (worse ever)” “Pale or discolored skin” “Sleepy, difficult to rouse, confused” “I feel like I might die” “Short of breath” For any combination of these symptoms, call 911 or get to the hospital.  Say, “I AM CONCERNED ABOUT SEPSIS.” It could save a life.