In a nutshell This study investigated the best first-line therapy to add to bevacizumab (Avastin) treatment in patients with metastatic (spread to other parts of the body) colorectal cancer (mCRC). Researchers suggested that irinotecan (Camptosar) plus bevacizumab improved the outcomes of these patients. Some background Colorectal cancer is...
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In a nutshell This study investigated the outcomes of patients with rectal cancer who were followed up with the watch and wait method after chemoradiotherapy (CRT). Researchers suggested that this strategy can effectively identify patients who can have a less frequent follow-up if they maintain response for the first 3 years...
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In a nutshell This study compared the effectiveness of open surgery (OS) and robotic surgery (RS) in patients with rectal cancer. Researchers suggested that RS and OS provided similar treatment outcomes in these patients. Some background Colorectal cancer is one of the most common cancer worldwide. Rectal cancer makes up for one-third of these cases....
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In a nutshell This study investigated the effectiveness and safety of regorafenib (Stivarga) treatment in older patients with colorectal cancer (CRC). Researchers suggested that this treatment has similar effects in younger and older patients. Some background CRC is the third most common cancer worldwide. More than half are diagnosed in patients older...
Read MoreIn a nutshell This study investigated the safety and effectiveness of TAS-102 (trifluridine-tipiracil) with and without bevacizumab (Avastin) therapy in metastatic colorectal cancer (mCRC). Researchers suggested that this combined therapy might be a good treatment option for patients with advanced CRC. Some background Colorectal cancer is the third...
Read MoreIn a nutshell This study investigated the effectiveness of chemotherapy after surgery in stage 2 colorectal cancer (CRC). Researchers suggested that this treatment may result in survival improvement but should be individualized. Some background CRC affects 145,600 adults in the US every year. Treatment for this disease is guided by stage at...
Read MoreIn a nutshell This study investigated the outcomes of patients with BRAF-positive colorectal cancer liver-metastasis (CRLM; spread to the liver) undergoing surgery. Researchers suggested that surgery is associated with improved outcomes for these patients. Some background Colorectal cancer is one of the most common cancers in the US. Around 25% of...
Read MoreIn a nutshell This phase 2 trial will investigate the effectiveness of genetically-engineered cell treatment (GECT) in advanced cancer. The main outcome will be the response to treatment. This trial is recruiting at the National Cancer Institute, Maryland, US. The details There are limited treatment options for advanced cancer. One...
Read MoreIn a nutshell This study aimed to investigate two techniques used to treat low rectal cancer, abdominoperineal resection (APR) and intersphincteric resection (ISR). This study found there was no significant difference in long-term outcomes for APR and ISR. Some background APR is a common surgery to remove low rectal cancers. A low rectal...
Read MoreIn a nutshell This phase 2 trial is investigating the effectiveness of a treatment combination to treat metastatic (spread to other parts of the body) colorectal cancer that has not responded to prior therapy. The main outcome to be measured is response to treatment on imaging. This trial is taking place in Colorado, United...
Read MoreIn a nutshell This study investigated the safety of localized surgery followed by chemotherapy compared with total mesorectal excision (TME; bowel and lymph nodes around the tumor are removed) in early stages (T0 to T1) of rectal cancer. Researchers suggested that local surgery followed by chemotherapy improves long term outcomes in early stages of...
Read MoreIn a nutshell This study looked at the effect of chemoradiation (CRT) and local surgical treatment (local excision – LE) on quality of life in patients with stage II rectal cancer. It found that this treatment had little effect on lower bowel function (anorectum) and quality of life. Some background...
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