In a nutshell This phase 2 trial will investigate the effectiveness of genetically-engineered cell treatment (GECT) in advanced cancer. The main outcome will be the response to treatment. This trial is recruiting at the National Cancer Institute, Maryland, US. The details There are limited treatment options for advanced cancer. One...
Read MoreType(s) of colorectal cancer (CRC)-Adenocarcinoma of the rectum Posts on Medivizor
Looking for patients with advanced BRAF positive colorectal cancer to test an immunotherapy treatment
In a nutshell This trial is examining the effectiveness and safety of encorafenib (Braftovi), binimetinib (Mektovi) and cetuximab (Erbitux) in patients with advanced colorectal cancer. The main outcome to be measured will be tumor response to the treatment. The details Colorectal cancer is the third most common cancer worldwide. A high number of...
Read MoreLooking for patients with metastatic colorectal cancer to test a new treatment
In a nutshell This trial is examining the effectiveness and safety of a combined treatment with pembrolizumab (Keytruda) and binimetinib (Mektovi). The main outcome to be measured is the tumor response to the treatment. This trial is recruiting in the United States and Canada. The details Colorectal cancer is the third most common cancer in the...
Read MoreLooking for participants to test a new vaccine to treat advanced colorectal cancer
In a nutshell This trial is examining the effectiveness and toxicity of PolyPEPI1018 vaccine in the treatment of advanced colorectal cancer. The main outcome to be measured is tumor response to the treatment. This trial will be conducted in Italy, and Minnesota, US. The details The standard treatment for metastatic (spread to other parts of the body)...
Read MoreLooking for participants with advanced colorectal cancer to test a new cancer vaccine
In a nutshell This trial is examining the effectiveness of a new cancer vaccine. The main outcomes to be measured are cancer response and side effects. This trial is recruiting in New York and Tennessee, US. The details The standard treatment for most cancers is surgery and chemotherapy. However, chemotherapy has a limited effectiveness and a high...
Read MoreComparing two types of surgery for low rectal cancers
In a nutshell This study aimed to investigate two techniques used to treat low rectal cancer, abdominoperineal resection (APR) and intersphincteric resection (ISR). This study found there was no significant difference in long-term outcomes for APR and ISR. Some background APR is a common surgery to remove low rectal cancers. A low rectal...
Read MoreLooking for patients with unresponsive colorectal cancer to test a combined immunotherapy
In a nutshell This phase 2 trial is investigating the effectiveness of a treatment combination to treat metastatic (spread to other parts of the body) colorectal cancer that has not responded to prior therapy. The main outcome to be measured is response to treatment on imaging. This trial is taking place in Colorado, United...
Read MorePost-surgery chemotherapy in early rectal cancer is associated with improved outcomes
In a nutshell This study investigated the safety of localized surgery followed by chemotherapy compared with total mesorectal excision (TME; bowel and lymph nodes around the tumor are removed) in early stages (T0 to T1) of rectal cancer. Researchers suggested that local surgery followed by chemotherapy improves long term outcomes in early stages of...
Read MoreDoes chemoradiation with surgical removal affect bowel function and quality of life?
In a nutshell This study looked at the effect of chemoradiation (CRT) and local surgical treatment (local excision – LE) on quality of life in patients with stage II rectal cancer. It found that this treatment had little effect on lower bowel function (anorectum) and quality of life. Some background...
Read MoreTAS-102 chemotherapy to treat progressive colorectal cancer
In a nutshell This study reviews the value of TAS-102 in the treatment of colorectal cancer that has progressed with other therapies. Researchers suggested that TAS-102 is an important treatment option for patients with progressive colorectal cancer. Some background Colorectal cancer is the third most frequently diagnosed cancer in men and the...
Read MoreLooking for participants to test the effectiveness of AZD1775 to treat metastatic colorectal cancer
In a nutshell The aim of this phase 1 trial is to study the effectiveness of treatment with AZD1775 combined with the chemotherapy irinotecan (Camptosar). The main outcome to be measured is the tumor response to the treatment and toxicity. The details Chemotherapy is a standard treatment to colorectal cancer. It reduces symptoms and prolongs...
Read MoreLooking for participants with metastatic colorectal cancer to undergo treatment with targeted therapy
In a nutshell The aim of this phase 2 trial is to compare the effectiveness of the combined treatment with chemotherapy, avelumab (Bavencio) and the vaccine Ad-CEA in patients with metastatic (spread to other parts of the body) colorectal cancer. The main outcome to be measured is tumor response to the treatment. This trial will recruit in Maryland,...
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