In a nutshell This trial is searching for patients to try a combination of glasdegib (Daurismo) with azacitidine (Vidaza) for acute myeloid leukemia (AML) that has not been treated. The main outcome that will be measured is overall survival. The details Different anti-cancer drugs can be used in different combinations and may have different effects....
Read MoreType of leukemia-Acute Myeloid Leukemia (AML) Posts on Medivizor
Low platelet counts and survival of patients with acute myeloid leukemia
In a nutshell This study wanted to find out if a low platelet count at diagnosis of acute myeloid leukemia (AML) was linked to rates of survival. Researchers found that low platelet count at diagnosis was linked to higher survival in these patients. Some background Acute myeloid leukemia (AML) is a cancer of the bone marrow. It may lead to an...
Read MoreThe negative impact of aspergillosis in acute leukemia
In a nutshell This study examined the impact of aspergillosis lung infection on the outcomes of patients with acute leukemia. Researchers found that this infection can reduce survival in these patients. Some background Acute leukemia is a cancer of the bone marrow. This leads to an abnormal immune system. Aspergillosis is a fungal infection that...
Read MoreGraft-versus-host disease in pediatric patients with acute leukemia after alloSCT
In a nutshell This study investigated the occurrence of graft-versus-host disease (GVHD) in pediatric patients who underwent an allogeneic stem cell transplant (alloSCT). This study concluded that both umbilical cord blood cells and bone marrow cells led to similar rates of GVHD in children with acute leukemia. Some background Allogeneic stem cell...
Read MoreComparing frontline therapies in older patients with acute myeloid leukemia
In a nutshell This study aimed to compare frontline therapies in older patients with acute myeloid leukemia. This study concluded that hypomethylating agents provided better overall survival for these patients. Some background Older patients with acute myeloid leukemia (AML), more frequently...
Read MoreComparing post remission therapies in older patients with acute myeloid leukemia
In a nutshell This study aimed to compare post-remission therapies for older patients with acute myeloid leukemia who are in complete remission. This study concluded that stem cell transplantation is more effective as a post-remission therapy than consolidation chemotherapy, but with more risks early-on. Some background...
Read MoreChemotherapy regimens for patients with relapsed or unresponsive acute myeloid leukemia
In a nutshell This study aimed to compare outcomes of fludarabine–treosulfan (FT), thiotepa–busulfan–fludarabine (TBF), and fludarabine, Ara-C, amsacrine, total body irradiation/busulfan, cyclophosphamide (FLAMSA) in the treatment of patients with relapsed or unresponsive acute myeloid leukemia (AML). The study found that all...
Read MoreCombining pracinostat and azacitidine to treat older patients with newly diagnosed acute myeloid leukemia
In a nutshell This study aimed to investigate the safety and effectiveness of the combination of pracinostat and azacitidine in patients aged over 65 with newly diagnosed acute myeloid leukemia. This study concluded that this combination is a safe and effective for treating this group of patients. Some background Pracinostat is a new drug that...
Read MoreAllogenic hematopoietic stem cell transplant for patients with unresponsive acute myeloid leukemia
In a nutshell This study aimed to investigate the effectiveness of allogeneic hemopoietic stem cell transplant (alloHSCT) in patients with unresponsive acute myeloid leukemia. This study concluded that alloHSCT is the best treatment option for these patients. Some background Patients with unresponsive acute myeloid leukemia (AML) are those...
Read MoreCould hyperbaric oxygen therapy improve umbilical cord blood transplantation outcomes?
In a nutshell This study examined if hyperbaric oxygen therapy is safe and can improve outcomes in umbilical cord blood transplantation. This study concluded that the use of hyperbaric oxygen therapy before umbilical cord blood transplantation is safe and can improve outcomes in certain patients. Some background Stem cells allow the production...
Read MoreIs venetoclax with decitabine or azacitidine effective in treating elderly patients with acute myeloid leukemia?
In a nutshell This study examined If venetoclax (Venclexta) with decitabine (Dacogen) or azacitidine (Vidaza) is effective in treating elderly patients with acute myeloid leukemia (AML). This study concluded that venetoclax with decitabine or azacitidine could be an effective treatment in these patients. Some background Acute...
Read MoreSearching for patients with relapsed or unresponsive acute myeloid leukemia to test a new treatment
In a nutshell This trial is examining the effectiveness of a new drug called uproleselan for patients with acute myeloid leukemia (AML). The main outcome to be measured will be overall survival. This study is being conducted in the United States. The details Acute myeloid leukemia (AML) is a cancer of the bone marrow. It leads to an abnormal immune...
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