In a nutshell This study aimed to investigate the safety and effectiveness of the combination of all-trans-retinoic acid (Vesanoid), arsenic trioxide (Trisenox), and idarubicin (Idamycin) as front-line treatment for acute promyelocytic leukemia. This study concluded that this combination is safe and effective for these...
Read MoreType of leukemia-Acute Myeloid Leukemia (AML) Posts on Medivizor
Comparing salvage regimes for patients with relapsed/refractory acute myeloid leukemia
In a nutshell This study aimed to compare two salvage regimes for patients with relapsed/refractory acute myeloid leukemia. This study concluded that both regimens have similar effectiveness in terms of overall response but one shows a significant reduction in side effects in these patients. Some background...
Read MoreImpact of graft cryopreservation on allogeneic hematopoietic stem cell transplant outcomes using post-transplant cyclophosphamide
In a nutshell This study aimed to compare outcomes of allogeneic hematopoietic stem cell transplant (alloHSCT) using cryopreserved (frozen) and fresh grafts in patients with blood cancers who received post-transplant cyclophosphamide (Cytoxan). This study concluded that cryopreservation (CP) does...
Read MoreDifferentiation syndrome in patients of IDH-mutated acute myeloid leukemia treated with ivosidenib and enasidenib
In a nutshell The study evaluated the occurrence of differentiation syndrome (DS) in patients with IDH-mutated acute myeloid leukemia (AML) under ivosidenib (Tibsovo) and enasidenib (Idhifa) therapy. The authors found that DS is a common and adverse condition in such patients. Some background Mutations or changes in the isocitrate dehydrogenase (IDH)...
Read MoreThe effects of smoking on predicted treatment outcomes in patients with acute myeloid leukemia
In a nutshell The study evaluated how smoking habits affect the predicted treatment outcomes in patients with acute myeloid leukemia (AML) under intense chemotherapy. The authors found that smoking status was related to poor overall survival in such patients. Some background Patient-related factors such as lifestyle choice and additional medical...
Read MoreTreating patients with high risk acute promyelocytic leukemia (APL) with ATRA, arsenic trioxide and gemtuzumab ozogamicin
In a nutshell The study evaluated the effectiveness and safety of combing all-trans retinoic acid (ATRA; Vesanoid), arsenic trioxide (ATO; Trisenox), and gemtuzumab ozogamicin (GO; Milotarg) in treating patients with high risk (HR) acute promyelocytic leukemia (APL). The authors found that the combination therapy was effective and well...
Read MoreDo stem cell transplants improve patients’ long-term survival?
In a nutshell This study examined the long-term survival of patients who received stem cell transplants (SCT) and compared them to the general population. The authors found that patients who received SCTs had almost the same chance of survival as the general population and identified factors that alter this chance. Some background Treatments such as...
Read MoreComparing outcomes in acute myeloid leukemia patients treated with FLAG with/without idarubicin vs traditional 3+7 treatment
In a nutshell This study aimed to compare post-remission survival for patients with acute myeloid leukemia treated with 2 different regimens. This study concluded that FLAG with or without idarubicin treatment has better post-remission survival when compared to standard 3+7 treatment for these patients. Some background...
Read MoreClofarabine, cytarabine and mitoxantrone for the treatment of relapsed/refractory acute myeloid leukemia
In a nutshell This study aimed to investigate the effectiveness and safety of clofarabine, cytarabine, and mitoxantrone (CLAM) in relapsed or refractory (unresponsive) acute myeloid leukemia. This study concluded that this combination was safe and effective in these patients. Some...
Read MoreGemtuzumab ozogamicin treatment in acute myeloid leukemia
In a nutshell This study aimed to investigate if gemtuzumab ozogamicin with induction and consolidation treatment was suitable for patients with acute myeloid leukemia and abnormal genes. This study concluded that patients who achieve complete remission after induction therapy and treated with gemtuzumab ozogamicin had...
Read MoreLooking for patients with AML to try a combination treatment
In a nutshell This trial is evaluating the effectiveness of KRT-232 for the treatment of acute myeloid leukemia (AML). The main outcomes are the number of patients who achieve complete remission, and how many patients stop treatment due to side effects. This study is being conducted in Columbus, Ohio, United States. The details AML is a...
Read MoreWhat factors can predict the success of stem cell transplantation?
In a nutshell This study evaluated the risk factors associated with delayed engraftment (DE) in patients who had stem cell transplantation (SCT). The authors found that patients receiving blood transfusions, those with low platelet levels, and those given low numbers of stem cells during SCT were more likely to experience DE. Some background...
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