In a nutshell The study compared the effectiveness of letrozole (Femara)/gonadotropin combination to letrozole alone in infertile women with polycystic ovarian syndrome (PCOS). The study found that the combination of letrozole/gonadotropin was more effective than letrozole alone in these women. Some background Polycystic ovarian syndrome or...
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In a nutshell This review looked at whether women who used fertility medications more often developed breast cancer later on. It found that women treated with ovarian stimulation had similar rates of breast cancer to other women. Some background Treatment for infertility has become common, both as people have children later, and as the condition is...
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In a nutshell This study looked at which factors can predict pregnancy following in vitro fertilization (IVF) for patients with a poor ovarian response (POR). It found that pregnancy was affected by age, body weight, ovarian reserve, and type of fertility medication. Some background For couples with infertility, IVF can greatly increase the chances of...
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In a nutshell This review compared starting ovarian stimulation (OS) for egg collection at the conventional time early in the menstrual cycle, to starting it in the luteal phase, late in the cycle. It found that both timelines led to successful egg collection. Using two collections in one cycle may improve outcomes for patients with a poor response to...
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In a nutshell This review compared mild-dose ovarian stimulation (OS) for in vitro fertilization (IVF) to standard higher dose OS. It found that mild OS has fewer side effects and similar birth rates. Some background The first stage of the infertility treatment IVF is to stimulate the ovaries. The most common type of medication used is gonadotropin...
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In a nutshell This review looked at how often artificial gonadotropin hormones such as human follitropin alpha (Gonal-F) caused ovarian hyperstimulation syndrome (OHSS) or blood clots. It found that these conditions are infrequent side effects of using gonadotropins to stimulate the ovaries. Some background In a natural menstrual cycle,...
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In a nutshell This study created a model to predict how well eggs (oocytes) develop embryos during in vitro fertilization (IVF). It found that patients with lower doses of gonadotropin (GN) hormones had better fertilization rates (FR). It also found that patients with diminished ovarian reserve (DOR) could have a high FR. Some background The...
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In a nutshell This study investigated live birth rates (LBRs) in women that underwent frozen (Fz) embryo transfer (ET). They found that LBRs were higher with Fz-ET in women under 35, but there was no difference between Fz and fresh (Fr) ET in those older than 35. Some background Infertility is a common condition. Assisted reproductive technology...
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In a nutshell This study investigated if controlled ovarian stimulation (COS) and progesterone (P) supplementation affects the microbiota (microorganisms found in the human body) of the vagina and uterus (womb). They found that COS alters the vaginal and uterine microbiota (VUM). Some background The rate of infertility is increasing worldwide. Many...
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In a nutshell This study investigated if a dual-trigger treatment (DTT) improves pregnancy outcomes in older women with diminished ovarian reserve (DOR). They found that DTT improved in vitro fertilization (IVF) outcomes in these women. Some background In vitro fertilization (IVF) is an assisted reproductive technique (ART). The first step of...
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In a nutshell This study investigated if inhibin A (IHA) is associated with oocyte maturation (OM) during ovarian stimulation (OS). They found that IHA levels are associated with OM. Some background Infertility is an increasing problem worldwide. Assisted reproductive techniques (ART) are used to treat infertility. Controlled ovarian stimulation...
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In a nutshell This study investigated a combined Stop GnRH agonist and multiple-dose GnRH antagonist protocol for patients with a previous poor ovarian response (POR). It found that this protocol may lead to a higher number of oocytes collected. Some background Patients with POR produce few oocytes (eggs) in response to ovarian stimulation (OS)...
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