In a nutshell This study examined whether immunotherapy with sipuleucel-T (Provenge) shows a greater immune response if administered before or after androgen deprivation therapy (ADT). Authors present preliminary evidence of improved immune cell response when sipuleucel-T was administered first in patients with recurrent prostate cancer at high risk of...
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In a nutshell This study examined evidence for the benefits of adding chemotherapy early to hormone therapy for metastatic prostate cancer. Authors concluded that early evidence indicates a survival benefit with the addition of chemotherapy for metastatic prostate cancer. Some background Androgen deprivation therapy (ADT) is a type of hormone...
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In a nutshell This study examined the effect of ethnicity on health outcomes with androgen deprivation therapy (ADT). Researchers reported shorter survival among African American men receiving ADT for low- or intermediate-risk prostate cancer compared to men of other ethnicities. Some background ADT is a type of hormone therapy used to treat...
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In a nutshell This study examined the relationship between androgen deprivation therapy (ADT) and the risk of falls. Authors present preliminary evidence suggesting that patients receiving ADT may be at increased risk of falls. Some background ADT is a type of hormone therapy commonly used to treat advanced prostate cancer. By reducing the levels...
Read MoreIn a nutshell This study examined the effect of combined radiation and hormone therapy on long-term fatigue. Researchers reported severe fatigue during and up to 4 years after treatment. Men with increased cancer markers and symptoms were more likely to report higher fatigue levels. Some background Radiation therapy and hormone therapy are often...
Read MoreIn a nutshell This review evaluated recent evidence on the management of high-risk prostate cancer. Primary treatment options for high-risk prostate cancer were generally associated with good effectiveness, but authors advised that risk assessment is in need of refinement and standardization. Some background About 15% of men with prostate cancer...
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In a nutshell This study examined the safety and effectiveness of androgen deprivation therapy (ADT) plus docetaxel (Taxotere) compared to ADT alone for metastatic prostate cancer. Researchers reported increased progression-free survival and overall survival when ADT was combined with docetaxel. Some background ADT is a type of hormone therapy...
Read MoreIn a nutshell This study examined the risk of cardiovascular disease (CVD) in men undergoing treatment with androgen deprivation therapy (ADT) for prostate cancer. Researchers reported an increased CVD risk in men undergoing ADT within the first year of treatment. CVD risk was dependent on the type of ADT and the patient’s history. Some...
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In a nutshell This review evaluated current evidence on combination therapies for metastatic hormone-sensitive prostate cancer (mHSPC). Authors concluded that results are promising for the combination of taxane-based chemotherapies and alternative hormone therapies with androgen deprivation therapy (ADT). Some background ADT is a type of hormone...
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In a nutshell This review compared the potential risks and benefits of two hormone therapies available for androgen deprivation therapy (ADT). Authors concluded that GnRH antagonists offer a safe and effective alternative to GnRH agonists. Some background ADT is a type of hormone therapy commonly used to treat advanced prostate cancer. ADT targets...
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In a nutshell This study examined factors important in the treatment of localized prostate cancer with androgen deprivation therapy (ADT). Researchers reported a number of specific markers that can help determine the risk of cancer progression after ADT. Some background Androgen deprivation therapy (ADT) is a type of hormone therapy that targets...
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In a nutshell This study compared intermittent and continuous androgen deprivation therapy (ADT) in treating locally advanced prostate cancer. Researchers reported that both intermittent and continuous ADT were equally as effective and well-tolerated. Some background ADT is a type of hormone therapy that blocks male hormones (such as testosterone)...
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