In a nutshell This study evaluated the safety and effectiveness of an experimental treatment, lurbinectedin, in patients with small-cell lung cancer (SCLC) after unsuccessful treatment with platinum-based chemotherapy. The authors found that this treatment showed promising effectiveness and manageable side effects in these...
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In a nutshell This study evaluated the outcomes of vaccination in children with acute lymphoblastic leukemia (ALL). This study found that children had less vaccine protection after chemotherapy. Some background Vaccines help the immune system recognize a pathogen using dead or weakened bacteria or viruses. Vaccines are not effective if someone’s...
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In a nutshell This study looked at combining chemotherapy with dasatinib (Sprycel) to treat patients with acute myeloid leukemia (AML) with a CBF mutation. This study found that dasatinib was a safe and effective treatment for these patients. Some background AML is a cancer of immature blood cells called myeloid cells. Around 12% of AML cases...
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In a nutshell This study evaluated whether the risk and severity of asparaginase-associated pancreatitis (AAP) depend on the age of patients with acute lymphoblastic leukemia (ALL). The main finding was that the AAP risk was higher in adolescents and adults compared to younger children. Some background Asparaginase (ASP; Oncaspar) is an important...
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In a nutshell This study evaluated the safety and effectiveness of ESHAOx chemotherapy for patients with Hodgkin's lymphoma (HL) that has come back or stopped responding to treatment. This study found that this regimen is effective, with manageable side effects. Some background Most patients with HL respond well to initial treatment. However, some...
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In a nutshell This study compared the effectiveness and safety of acalabrutinib (Calquence) to other targeted therapies for patients with mantle cell lymphoma (MCL). The authors found that acalabrutinib was just as safe and more effective for these patients. Some background MCL is a type of non-Hodgkin's lymphoma treated in...
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In a nutshell This study investigated the role of oxaliplatin (Eloxatin) in treating patients with rectal cancer after surgery. Researchers suggested that this drug may be a good option in the treatment of rectal cancer. Some background Chemotherapy is one of the standard treatments for rectal cancer. It usually consists of...
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In a nutshell This study compared different treatment combinations for first-line and maintenance therapies in elderly patients with multiple myeloma (MM). The authors found that first-line MPR was most effective for fit elderly patients, while all patients benefitted from RP maintenance therapy. Some background MM is a complex disease, and...
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In a nutshell This study evaluated camrelizumab (SHR 1210) for patients with classical Hodgkin's Lymphoma (cHL) that has come back or is resisting treatment. The authors concluded that this drug is a safe and effective treatment for these patients. Some background After initial treatment, 5-10% of patients with cHL do not...
Read MoreIn a nutshell This phase 2 trial will investigate the effect of gemcitabine (Gemzar) and nivolumab (Opdivo) in patients with metastatic small-cell lung cancer (SCLC). The main outcome will be the radiographic response rate (RRR). This trial is recruiting in North Carolina, US. The details Small cell lung cancer...
Read MoreIn a nutshell This study aimed to investigate if venetoclax would enable patients with acute myeloid leukemia to overcome disease progression after hypomethylating agents. This study concluded that adding venetoclax to these patient's treatment may result in a substantial...
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In a nutshell This study compared the effectiveness and safety of low and high dose leucovorin (folinic acid) in the treatment of colorectal cancer. Researchers suggested that low dose leucovorin might be a safe treatment option for these patients. Some background Colorectal cancer is the fourth leading cause of death by cancer. This cancer frequently...
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