In a nutshell This study investigated the role of oxaliplatin (Eloxatin) in treating patients with rectal cancer after surgery. Researchers suggested that this drug may be a good option in the treatment of rectal cancer. Some background Chemotherapy is one of the standard treatments for rectal cancer. It usually consists of...
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Evaluating lenalidomide-based regimens for elderly patients with multiple myeloma
In a nutshell This study compared different treatment combinations for first-line and maintenance therapies in elderly patients with multiple myeloma (MM). The authors found that first-line MPR was most effective for fit elderly patients, while all patients benefitted from RP maintenance therapy. Some background MM is a complex disease, and...
Read MoreIs camrelizumab effective for recurring or resistant classical Hodgkin’s lymphoma?
In a nutshell This study evaluated camrelizumab (SHR 1210) for patients with classical Hodgkin's Lymphoma (cHL) that has come back or is resisting treatment. The authors concluded that this drug is a safe and effective treatment for these patients. Some background After initial treatment, 5-10% of patients with cHL do not...
Read MoreSearching patients with small cell lung cancer to test a chemoimmunotherapy combination
In a nutshell This phase 2 trial will investigate the effect of gemcitabine (Gemzar) and nivolumab (Opdivo) in patients with metastatic small-cell lung cancer (SCLC). The main outcome will be the radiographic response rate (RRR). This trial is recruiting in North Carolina, US. The details Small cell lung cancer...
Read MoreVenetoclax in patients with acute myeloid leukemia where hypomethylating agents have failed
In a nutshell This study aimed to investigate if venetoclax would enable patients with acute myeloid leukemia to overcome disease progression after hypomethylating agents. This study concluded that adding venetoclax to these patient's treatment may result in a substantial...
Read MoreIs low dose leucovorin an effective and safe treatment option for colorectal cancer?
In a nutshell This study compared the effectiveness and safety of low and high dose leucovorin (folinic acid) in the treatment of colorectal cancer. Researchers suggested that low dose leucovorin might be a safe treatment option for these patients. Some background Colorectal cancer is the fourth leading cause of death by cancer. This cancer frequently...
Read MoreSearching for patients with triple negative breast cancer to test durvalumab and olaparib
In a nutshell This phase 2 study will investigate the safety and effectiveness of olaparib (Lynparza) alone or in combination with durvalumab (Infinzi) in advanced triple negative breast cancer (TNBC). The main outcome will be progression-free survival (PFS). This study is recruiting in Durham, North Carolina, US. The details...
Read MoreSearching for patients with lung cancer that cannot be operated on to test durvalumab after chemotherapy and radiation
In a nutshell This phase 2 trial will investigate the safety and effectiveness of durvalumab (Imfinzi) in patients with stage III non-small cell lung cancer (NSCLC). The main outcomes will be the number of treatment-related adverse events (TRAEs) and progression-free survival (PFS). The details Non-small cell lung cancer (NSCLC)...
Read MorePET scans in determining outcomes for patients with Hodgkin lymphoma treated with chemotherapy
In a nutshell This study aimed to investigate the role of positron emission tomography (PET; an imaging technique) in determining the outcomes for patients with Hodgkin lymphoma treated with chemotherapy. This study concluded that negative-PET scans after chemotherapy predict good outcomes for these patients, regardless of stage at...
Read MoreEvaluating palbociclib for patients with previously treated breast cancer
In a nutshell This study evaluated how well palbociclib (Ibrance) works in patients with breast cancer who received multiple lines of previous therapy. This study found that palbociclib was effective for these patients. Some background There are several different treatments for breast cancer depending on the types of...
Read MoreSearching for patients with non-small cell lung cancer to trial a new targeted therapy drug
In a nutshell This phase 3 trial will investigate the safety and effectiveness of osimertinib (Tagrisso) after chemoradiation (CR) in non-small cell lung cancer (NSCLC). The main outcome will be progression-free survival (PFS; survival without cancer growing or spreading). The details Non-small cell lung cancer (NSCLC) is the most...
Read MoreThe frequency of advanced colorectal neoplasia in Hodgkin lymphoma survivors
In a nutshell This study aimed to investigate the frequency of advanced colorectal neoplasia (ACN; abnormal growth of tissue in the bowel) in Hodgkin lymphoma (HL) survivors. This study concluded that HL survivors treated with abdominal radiotherapy and/or alkylating chemotherapy have a high frequency of ACN. Some background...
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