In a nutshell This study aimed to investigate the effectiveness of lenalidomide consolidation therapy after chemoimmunotherapy for patients with chronic lymphocytic leukemia. This study concluded that this regimen improves outcomes for these patients. Some background Fludarabine (Fludara) is a chemotherapy used for the treatment of chronic lymphocytic...
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Sequential treatment for patients with chronic lymphocytic leukemia who have received bendamustine
In a nutshell This study aimed to investigate the effectiveness of obinutuzumab and venetoclax after bendamustine treatment in patients with chronic lymphocytic leukemia (CLL). This study concluded that this sequence of treatment caused no unexpected side effects. It also concluded that the outcomes were comparable to established therapies for CLL. Some...
Read MoreCongestive heart failure in children with acute leukemia
In a nutshell This study identified the risks and incidence of congestive heart failure in children with acute leukemia (ALL or AML). The study found that risks of heart failure with ALL or AML included female gender and diagnosis at a younger age. Some background Congestive heart failure (CHF) is a condition in which the heart is unable to pump blood...
Read MoreEvaluating the effectiveness of stem cell transplant in patients with follicular lymphoma with early treatment failure
In a nutshell This study investigated the effectiveness of autologous stem cell transplantation (autoSCT) for patients with follicular lymphoma who experienced early treatment failure (ETF; relapse or disease progression within 2 years after first-line therapy). This study concluded that autoSCT may be an effective option for these patients. Some...
Read MoreComparing open and laparoscopic surgery for patients with rectal cancer
In a nutshell This study compared the outcomes of patients with rectal cancer treated with either laparoscopy (LPS; removal of the tumor by using a cable with a camera inserted near the tumor) or open surgery. Researchers found no differences in outcomes between LPS and open surgery for these patients. Some background Treatment for rectal...
Read MoreComparing chemoimmunotherapy and ibrutinib treatment in patients with chronic lymphocytic leukemia
In a nutshell This study aimed to compare the outcomes of patients with chronic lymphocytic leukemia who received chemoimmunotherapy or ibrutinib. This study suggested that ibrutinib may have more favorable outcomes for these patients when compared to chemoimmunotherapy. Some background Chemoimmunotherapy (CIT) is a treatment option that can be used...
Read MoreEvaluating the risk of developing acute myeloid leukemia or myelodysplastic syndrome after a stem cell transplant
In a nutshell This study evaluated the risk of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) development in patients with lymphoma and myeloma after an autologous stem cell transplant (autoSCT). This study concluded that this risk is quite high after autoSCT in these patients. Some background AML and MDS are known long-term...
Read MoreMaintenance rituximab plus bortezomib for mantle cell lymphoma
In a nutshell This study investigated the safety and effectiveness of rituximab (Rituxan) plus bortezomib (Velcade) for patients with mantle cell lymphoma after stem cell transplant. This study concluded that this combination is a safe and effective regimen in these patients. Some background The standard treatment for younger patients with mantle cell...
Read MoreObinutuzumab treatment for patients with chronic lymphocytic leukemia
In a nutshell This study aimed to investigate the safety of obinutuzumab (Gazyva) in a range of patients with chronic lymphocytic leukemia. This study concluded that obinutuzumab is safe and tolerable for a range of patients with chronic lymphocytic leukemia. Some background Obinutuzumab is a targeted therapy for chronic lymphocytic...
Read MoreIs plerixafor a safe addition to chemotherapy treatment for AML?
In a nutshell This study looked at the safety and effectiveness of adding plerixafor (Mozibil) to FLAG-Ida (fludarabine [Fludara], idarubicin [Idamycin], cytarabine [Cytosar-U] and G-CSF) in the treatment of patients with relapsed acute myeloid leukemia. The study found that adding plerixafor to FLAG-Ida treatment (together called PLERIFLAG) was a safe...
Read MoreDoes graft versus host disease affect relapse and survival rates after a stem cell transplant in childhood leukemia?
In a nutshell This study examined the effect of graft versus host disease on relapse rates in children with acute leukemia. This study concluded that graft versus host disease may protect against relapse, but they did not see an effect on survival. Some background One complication following an allogeneic stem cell transplant (transplant using donor...
Read MoreDoes radiotherapy improve outcomes for patients with primary breast diffuse large B-cell lymphoma?
In a nutshell This study evaluated the impact of radiotherapy on the outcomes of rituximab (Rituxan)-treated patients with primary breast diffuse large B-cell lymphoma. This study concluded that radiotherapy has significant therapeutic benefits for these patients. Some background Primary breast diffuse large B-cell lymphoma (DLBCL) is a rare type of...
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