In a nutshell This study investigated the effect of thoracic tumor radiotherapy on overall survival (OS) in patients with metastatic non-small-cell lung cancer (NSCLC) with malignant pleural effusion (MPE). The authors concluded that thoracic tumor radiotherapy effectively improved OS with acceptable toxicity levels in these patients. Some background...
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What is the effect of weight-loss surgery on psychological health in patients with type 2 diabetes and obesity?
In a nutshell This study investigated the psychological impact of Roux-en-Y gastric bypass with silastic ring (SR-RYGB) or sleeve gastrectomy (SG) in patients with type 2 diabetes (T2D) and obesity and associations with improved symptoms of depression and quality of life (QoL). The study showed that both types of bariatric (weight-loss) surgery were...
Read MoreEvaluating the effectiveness of robot-assisted gait training with various training modes in improving the balance and walking function of patients with stroke.
In a nutshell This study evaluated the effectiveness of robot-assisted gait training with various training modes in improving the balance and walking function of patients with stroke. The data showed that robot-assisted gait training with various training modes significantly improved balance, walking function, and lower limb strength compared to...
Read MoreEvaluating the effectiveness and safety of maintenance therapy with panitumumab plus FOLFIRI in patients with RAS wild-type metastatic colorectal cancer.
In a nutshell This study evaluated the effectiveness and safety of panitumumab (Vectibix) rechallenge when added to maintenance therapy with FOLFIRI {fluorouracil (FU; Adrucil), folinic acid (FA; Leucovorin), irinotecan (Camptosar)} in patients with RAS wild-type metastatic colorectal cancer (mCRC). The data showed that maintenance therapy with...
Read MoreEvaluating the long-term effectiveness and safety of daratumumab plus bortezomib and dexamethasone in patients with relapsed or refractory multiple myeloma.
In a nutshell This study evaluated the long-term effectiveness and safety of daratumumab (D; Darzalex) plus bortezomib (V; Velcade) and dexamethasone (d; Decadron) (D-Vd) regimen in patients with relapsed or refractory (r/r) multiple myeloma (MM). The data showed that the D-Vd regimen significantly increased the overall survival in these patients. Some...
Read MoreEvaluating the outcomes of invasive versus conservative strategies in older patients with non-ST elevation myocardial infarction.
In a nutshell This study evaluated the outcomes of invasive versus conservative strategies in patients older than 70 years with non-ST elevation myocardial infarction (NSTEMI). The data showed that an initial invasive strategy was associated with a significantly lower risk of major cardiac and cerebrovascular events and unplanned revascularization...
Read MoreAnalyzing the effectiveness and safety of abatacept for rheumatoid arthritis
In a nutshell The study investigated the effectiveness and safety of abatacept (Orencia) for patients with rheumatoid arthritis (RA). The analysis concluded that abatacept gave better results to patients with RA compared to other biologic drugs. Some background RA is a common autoimmune disorder that affects the joints. This condition...
Read MoreEvaluating the effectiveness and safety of brentuximab vedotin plus nivolumab consolidation therapy after autologous hematopoietic stem-cell transplantation in patients with high-risk classic Hodgkin lymphoma.
In a nutshell This study evaluated the effectiveness and safety of brentuximab vedotin (BV; Adcetris) plus nivolumab (Opdivo) consolidation therapy after autologous hematopoietic stem-cell transplantation (HSCT) in patients with high-risk relapsed or refractory (r/r) classical Hodgkin lymphoma (cHL). The data showed that the BV plus nivolumab combination...
Read MoreEvaluating the effectiveness and safety of platelet rich plasma for the treatment of erectile dysfunction.
In a nutshell This study evaluated the effectiveness and safety of platelet-rich plasma (PRP) injections for the treatment of patients with mild and moderate erectile dysfunction (ED). The data showed that PRP was a safe and promising treatment for improving mild to moderate ED. Some background Erectile dysfunction (ED) consists of the inability to...
Read MoreEvaluating the effectiveness and safety of Quisqualis indica extract for the treatment of patients with lower urinary tract symptoms.
In a nutshell This study evaluated the effectiveness and safety of Quisqualis indica (Rangoon creeper or Chinese honeysuckle; a type of plant) extract for the treatment of patients with lower urinary tract symptoms (LUTS). The data showed that Quisqualis indica extract was safe and effective for the treatment of these patients. Some background Benign...
Read MoreEvaluating the long-term effectiveness and safety of fixed-duration combination of ibrutinib plus obinutuzumab-based immunochemotherapy for patients with chronic lymphocytic leukemia.
In a nutshell This study reported the long-term effectiveness and safety of the fixed-duration combination of ibrutinib (Imbruvica) plus obinutuzumab (Gazyva)–based immunochemotherapy for patients with previously untreated chronic lymphocytic leukemia (CLL). The data showed that a fixed-duration combination of ibrutinib plus obinutuzumab-based...
Read MoreHow safe and effective is prophylactic cranial irradiation in patients with extensive stage small cell lung cancer?
In a nutshell This study evaluated the effectiveness and safety of prophylactic cranial irradiation (PCI) in patients with extensive stage (ES) small cell lung cancer (SCLC). The data indicated that PCI may decrease the occurrence of brain metastases in patients with ES-SCLC and improve 1-year survival time, without improving the overall survival...
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