In a nutshell The study evaluated the long-term effectiveness and safety outcomes of adding abiraterone acetate (AA; Zytiga) and prednisolone (P; Deltasone) with or without enzalutamide (Xtandi) in patients with metastatic prostate cancer (PC) starting androgen-deprivation therapy (ADT). The data showed that enzalutamide and AA+P should not be combined...
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Evaluating the effects of dance style and training duration in improving balance in patients with Parkinson’s disease.
In a nutshell This study evaluated the effects of dance style and training duration in improving balance in patients with Parkinson’s disease (PD). The data showed that dance-based interventions of more than 12 weeks could effectively improve balance in these patients. Some background PD is a disorder in which part of the brain is progressively...
Read MoreEvaluating the effectiveness and safety of immune checkpoint inhibitors given before surgery for the treatment of resectable mucosal melanoma.
In a nutshell This study evaluated the effectiveness and safety of immune checkpoint inhibitors (ICIs) given before surgery for the treatment of patients with resectable mucosal melanoma. The data showed that ICIs given before surgery were effective with manageable side effects for these patients. Some background Melanoma is an aggressive type of skin...
Read MoreComparing the effectiveness and safety of chemotherapy-based combination therapies as first-line treatment for advanced non-small cell lung cancer with negative PD-L1.
In a nutshell This study compared the effectiveness and safety of chemotherapy-based combination therapies for the treatment of patients with advanced non-small cell lung cancer (NSCLC) with negative PD-L1 expression. The data showed that pembrolizumab (Keytruda) plus chemotherapy combination was the best treatment regimen for improving overall survival...
Read MoreEvaluating the effectiveness and safety of TAS-102 plus Yttrium-90 radioembolization for the treatment of patients with colorectal cancer liver metastasis.
In a nutshell This study evaluated the effectiveness and safety of TAS-102 (Lonsurf; trifluridine-tipiracil) plus Yttrium-90 (Y-90) radioembolization (RE) for patients with colorectal cancer liver metastasis (CRLM) who are unresponsive to chemotherapy. The data showed that TAS-102 plus RE was safe and effective in these patients. Some background...
Read MoreEvaluating the effectiveness of antibiotic bone cement for infected diabetic foot wounds
In a nutshell The study investigated the efficacy of antibiotic bone cement for infected diabetic foot wounds. The study found that antibiotic cement gave promising results for the management of diabetic foot-infected wounds. Some background Diabetes is a condition that affects the body’s blood glucose level. Diabetes requires constant treatment...
Read MoreComparing the effectiveness of combined therapy of bortezomib, melphalan, and prednisone with versus without daratumumab in patients with multiple myeloma ineligible for a transplant
In a nutshell The study evaluated the effectiveness of combined therapy of bortezomib (Velcade), melphalan (Alkeran), and prednisone (Deltasone) with (D-VMP) versus without (VMP) daratumumab (Darzalex) in transplant-ineligible patients newly diagnosed with multiple myeloma (MM). The study concluded that D-VMP was more effective than using...
Read MoreEvaluating the long-term effectiveness and safety of nivolumab and AVD chemotherapy combination in patients with early-stage unfavorable classical Hodgkin lymphoma.
In a nutshell This study reported the long-term safety and effectiveness of nivolumab (Opdivo; N) + AVD (doxorubicin, vinblastine, and dacarbazine) chemotherapy combinations in patients with early-stage unfavorable classical Hodgkin lymphoma (cHL). The data showed that the N+AVD combination is safe and highly effective over the long term for these...
Read MoreEvaluating the effectiveness and safety of continuous subcutaneous foslevodopa-foscarbidopa for the treatment of motor fluctuations in patients with Parkinson’s disease.
In a nutshell This study evaluated the effectiveness and safety of continuous subcutaneous foslevodopa-foscarbidopa (ABBV-951) for the treatment of motor fluctuations in patients with Parkinson’s disease (PD). The data showed that continuous subcutaneous foslevodopa-foscarbidopa significantly improved motor fluctuations in these patients. Some...
Read MoreComparing the effectiveness and safety of 5 injections of OnabotulinumtoxinA versus the standard 20 injections for the treatment of patients with overactive bladder.
In a nutshell This study compared the effectiveness and safety of 5 injections of onabotulinumtoxinA (OBTA; Botox) versus the standard 20 injections for the treatment of patients with overactive bladder (OAB). The study found that a reduced technique of 5 injections of OBTA was safe and as effective as the standard technique of 20 injections for the...
Read MoreDoes statin use improve survival outcomes in men with advanced prostate cancer undergoing androgen deprivation therapy?
In a nutshell This study evaluated the association between statin (cholesterol-lowering drugs) use and survival outcomes in men with advanced prostate cancer (PC) undergoing androgen deprivation therapy (ADT). The data showed that statin use improved the survival outcomes in these patients. Some background Metastatic prostate cancer (PC) is a form of...
Read MoreReducing chemotherapy-induced toxicities in patients with breast cancer using anti-diabetes medication metformin.
In a nutshell This study investigated the beneficial effects of co-administering anti-diabetes medication metformin (Glucophage) and doxorubicin (Adriamycin)-cyclophosphamide (Cytoxan) with paclitaxel (Taxol) (AC-T) chemotherapy in non-diabetic patients with breast cancer (BC). The data showed that metformin reduced the occurrence and severity of...
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