In a nutshell This study evaluated the effectiveness and safety of TAS-102 (Lonsurf; trifluridine-tipiracil) plus Yttrium-90 (Y-90) radioembolization (RE) for patients with colorectal cancer liver metastasis (CRLM) who are unresponsive to chemotherapy. The data showed that TAS-102 plus RE was safe and effective in these patients. Some background...
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Evaluating the effectiveness of antibiotic bone cement for infected diabetic foot wounds
In a nutshell The study investigated the efficacy of antibiotic bone cement for infected diabetic foot wounds. The study found that antibiotic cement gave promising results for the management of diabetic foot-infected wounds. Some background Diabetes is a condition that affects the body’s blood glucose level. Diabetes requires constant treatment...
Read MoreComparing the effectiveness of combined therapy of bortezomib, melphalan, and prednisone with versus without daratumumab in patients with multiple myeloma ineligible for a transplant
In a nutshell The study evaluated the effectiveness of combined therapy of bortezomib (Velcade), melphalan (Alkeran), and prednisone (Deltasone) with (D-VMP) versus without (VMP) daratumumab (Darzalex) in transplant-ineligible patients newly diagnosed with multiple myeloma (MM). The study concluded that D-VMP was more effective than using...
Read MoreEvaluating the long-term effectiveness and safety of nivolumab and AVD chemotherapy combination in patients with early-stage unfavorable classical Hodgkin lymphoma.
In a nutshell This study reported the long-term safety and effectiveness of nivolumab (Opdivo; N) + AVD (doxorubicin, vinblastine, and dacarbazine) chemotherapy combinations in patients with early-stage unfavorable classical Hodgkin lymphoma (cHL). The data showed that the N+AVD combination is safe and highly effective over the long term for these...
Read MoreEvaluating the effectiveness and safety of continuous subcutaneous foslevodopa-foscarbidopa for the treatment of motor fluctuations in patients with Parkinson’s disease.
In a nutshell This study evaluated the effectiveness and safety of continuous subcutaneous foslevodopa-foscarbidopa (ABBV-951) for the treatment of motor fluctuations in patients with Parkinson’s disease (PD). The data showed that continuous subcutaneous foslevodopa-foscarbidopa significantly improved motor fluctuations in these patients. Some...
Read MoreComparing the effectiveness and safety of 5 injections of OnabotulinumtoxinA versus the standard 20 injections for the treatment of patients with overactive bladder.
In a nutshell This study compared the effectiveness and safety of 5 injections of onabotulinumtoxinA (OBTA; Botox) versus the standard 20 injections for the treatment of patients with overactive bladder (OAB). The study found that a reduced technique of 5 injections of OBTA was safe and as effective as the standard technique of 20 injections for the...
Read MoreDoes statin use improve survival outcomes in men with advanced prostate cancer undergoing androgen deprivation therapy?
In a nutshell This study evaluated the association between statin (cholesterol-lowering drugs) use and survival outcomes in men with advanced prostate cancer (PC) undergoing androgen deprivation therapy (ADT). The data showed that statin use improved the survival outcomes in these patients. Some background Metastatic prostate cancer (PC) is a form of...
Read MoreReducing chemotherapy-induced toxicities in patients with breast cancer using anti-diabetes medication metformin.
In a nutshell This study investigated the beneficial effects of co-administering anti-diabetes medication metformin (Glucophage) and doxorubicin (Adriamycin)-cyclophosphamide (Cytoxan) with paclitaxel (Taxol) (AC-T) chemotherapy in non-diabetic patients with breast cancer (BC). The data showed that metformin reduced the occurrence and severity of...
Read MoreHow useful is thoracic tumor radiation in improving overall survival of patients with non-small-cell lung cancer and malignant pleural effusion?
In a nutshell This study investigated the effect of thoracic tumor radiotherapy on overall survival (OS) in patients with metastatic non-small-cell lung cancer (NSCLC) with malignant pleural effusion (MPE). The authors concluded that thoracic tumor radiotherapy effectively improved OS with acceptable toxicity levels in these patients. Some background...
Read MoreWhat is the effect of weight-loss surgery on psychological health in patients with type 2 diabetes and obesity?
In a nutshell This study investigated the psychological impact of Roux-en-Y gastric bypass with silastic ring (SR-RYGB) or sleeve gastrectomy (SG) in patients with type 2 diabetes (T2D) and obesity and associations with improved symptoms of depression and quality of life (QoL). The study showed that both types of bariatric (weight-loss) surgery were...
Read MoreEvaluating the effectiveness of robot-assisted gait training with various training modes in improving the balance and walking function of patients with stroke.
In a nutshell This study evaluated the effectiveness of robot-assisted gait training with various training modes in improving the balance and walking function of patients with stroke. The data showed that robot-assisted gait training with various training modes significantly improved balance, walking function, and lower limb strength compared to...
Read MoreEvaluating the effectiveness and safety of maintenance therapy with panitumumab plus FOLFIRI in patients with RAS wild-type metastatic colorectal cancer.
In a nutshell This study evaluated the effectiveness and safety of panitumumab (Vectibix) rechallenge when added to maintenance therapy with FOLFIRI {fluorouracil (FU; Adrucil), folinic acid (FA; Leucovorin), irinotecan (Camptosar)} in patients with RAS wild-type metastatic colorectal cancer (mCRC). The data showed that maintenance therapy with...
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