In a nutshell The study assessed whether pembrolizumab (Keytruda) could be used in addition to neoadjuvant chemotherapy (NAC; chemotherapy before surgery) to improve the outcomes of patients with early triple-negative breast cancer (TNBC). The study found that more patients treated with pembrolizumab had a complete response. Some...
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In a nutshell This study assessed whether olaparib (Lynparza) affected progression-free survival (PFS; survival without cancer worsening) in patients with metastatic castration-resistant prostate cancer (mCRPC) and certain genetic mutations (abnormalities). The study found that olaparib improved PFS in these patients. Some...
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In a nutshell This study looked at the effect of preimplantation genetic testing (PGT) on in vitro fertilization (IVF) outcomes for women with a poor ovarian response (POR). It found that PGT led to similar birth rates, but there were fewer miscarriages. Some background The first step of the infertility treatment IVF is to stimulate and collect...
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In a nutshell This article gives an overview of ovarian stimulation (OS) during assisted reproductive techniques (ART). Some background Many couples with infertility opt to use ART. In vitro fertilization (IVF) is an ART in which eggs are collected and fertilized embryos are implanted in the uterus. The first step of IVF is to cause...
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In a nutshell This study looked at MTX-HOPE (methotrexate, hydrocortisone, vincristine, sobuzoxane, etoposide) to treat patients over 70 with non-Hodgkin’s lymphoma (NHL) which had returned after previous treatments. It found that MTX-HOPE was an effective and safe treatment for these patients. Some background NHL is a group of cancers of the...
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In a nutshell The study assessed whether an initial invasive strategy (IS) for treating stable coronary artery disease (CAD) in patients with moderate or severe ischemia (reduced blood supply to the heart) have a better outcome when compared to a conservative strategy (CS). The study concluded that over the course of 3.2 years, invasive...
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In a nutshell This study aimed to compare two salvage regimes for patients with relapsed/refractory acute myeloid leukemia. This study concluded that both regimens have similar effectiveness in terms of overall response but one shows a significant reduction in side effects in these patients. Some background...
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In a nutshell This study examined if ABVD chemotherapy impacted fertility in female patients with Hodgkin lymphoma (HL). The authors found that ABVD reduced the levels of one of the fertility hormones and the type of fertility treatment patients opted for was not affected by ABVD. Some background Many patients with HL are young and fertility...
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In a nutshell This study examined how effective S-1 (Teysuno) chemotherapy is for patients with advanced non-small cell lung cancer (NSCLC) following initial chemotherapy treatment. The results showed that S-1 improved patients’ survival without NSCLC worsening but increased the number of side effects. Some background Treatment for patients...
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In a nutshell This study compared the effectiveness and safety of two different chemotherapies in the treatment of advanced colorectal cancer (CRC). Researchers suggested that S1-based chemotherapy is a good option for the treatment of these patients. Some background CRC is one of the most common cancers worldwide. The standard treatment is surgery...
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In a nutshell This study looked at the long-term risk of secondary cancers following brachytherapy (BT; internal radiation therapy) for prostate cancer. It found that treating prostate cancer with BT had a low risk of secondary cancers. Some background Prostate cancer is a slow-growing cancer of the prostate gland. Men with prostate cancer that has...
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In a nutshell This study examined the effectiveness and safety of biological therapy ranibizumab (Lucentis) for patients with diabetic macular edema (DME) that has never been treated. After one year, patients’ vision had improved significantly, particularly for patients who received 5 injections instead of 4. Some background Diabetic...
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