Welcome to Medivizor!

You're browsing our sample library. Feel free to continue browsing. You can also sign up for free to receive medical information specific to your situation.

Posted by on Jun 25, 2020 in Lung cancer | 0 comments

In a nutshell

This study examined how effective S-1 (Teysuno) chemotherapy is for patients with advanced non-small cell lung cancer (NSCLC) following initial chemotherapy treatment. The results showed that S-1 improved patients’ survival without NSCLC worsening but increased the number of side effects.

Some background

Treatment for patients with advanced (stage III or IV) NSCLC often proceeds in phases. The first phase is initial chemotherapy (induction). This is followed by lower doses of chemotherapy to keep the cancer at bay (maintenance therapy). 

Carboplatin (Paraplatin) is often used for induction chemotherapy. It was recently shown that S-1 chemotherapy improves treatment results. S-1 includes  tegafur, gimeracil, and oteracil. As S-1 is a tablet with fewer side effects than other chemotherapies, it might be useful as maintenance therapy.

Methods & findings

131 patients with advanced NSCLC were included in this study. Patients received carboplatin and S-1 induction chemotherapy. After this, the patients were divided into two groups. 67 patients received S-1 combined with another therapy of their clinician’s choice (CC) for maintenance therapy, while 64 patients received CC alone.

Patients in the S-1 plus CC group had a 45.2% higher chance of surviving without NSCLC becoming worse than patients in the CC alone group. Patients survived an average of 1.6 months before NSCLC became worse with S-1 plus CC and 1 month with CC alone.

S-1 did not change patients’ chances of survival overall. Patients in the S-1 plus CC group survived an average of 16.7 months and patients in the CC alone group survived 17.8 months.

S-1 increased the number of side effects patients experienced. The most common side effects experienced by patients in the S-1 plus CC group were lack of appetite (21.9%) and fatigue (20.3%). 82.8% of patients in the S-1 plus CC group had low red blood cells compared to 56.3% in the CC alone group.

The bottom line

The authors concluded that S-1 improved maintenance therapy results for patients but increased the number of side effects.

The fine print

The manufacturer of S-1, Taiho, funded this study. Patients received different maintenance therapies from their clinician which makes comparisons between the groups difficult. This study would benefit from including more patients.

Published By :


Date :

Jun 02, 2020

Original Title :

A randomized phase 3 study of maintenance therapy with S-1 plus best supportive care versus best supportive care after induction therapy with carboplatin plus S-1 for advanced or relapsed squamous cell carcinoma of the lung (WJOG7512L).

click here to get personalized updates