In a nutshell This trial is comparing the effectiveness and toxicity of ABT-165 or bevacizumab (Avastin) plus FOLFIRI (irinotecan, leucovorin, fluorouracil) chemotherapy in patients with metastatic (spread to other parts of the body) colorectal cancer. The main outcome to be measured will be tumor response and survival without cancer...
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In a nutshell This trial is examining the effectiveness of chemotherapy followed by a less invasive surgery for early rectal cancer. The main outcome will be the number of patients keeping their rectum. This trial is being conducted in Canada and the United States. The details Rectal cancer is one of the most common cancers in the US. The standard...
Read MoreIn a nutshell This trial aims to find out if targeted radiotherapy on the breast in women with low-risk breast cancer after breast-conserving surgery will prevent the cancer from coming back. The main outcome that will be measured is how long it takes before the breast cancer comes back. The study is being conducted in Canada and the United States. The...
Read MoreIn a nutshell This trial aims to find out if combining nivolumab (Opdivo) and ipilimumab (Yervoy) with chemotherapy in patients with advanced non-small cell lung cancer is more effective than only treating with chemotherapy. The main outcome that will be measured is overall survival. The details There are a number of different treatment options...
Read MoreIn a nutshell This trial aims to find out how well a new drug (DS-8201a) works on breast cancer that expresses low levels of the HER2 receptor and is not able to be operated on. The main outcome that will be measured is survival without cancer growing or spreading. The details The drug DS-8201a is a new anti-cancer drug that works against breast...
Read MoreIn a nutshell This trial aims to find out how well nivolumab (Opdivo) and temozolomide (Temodal) work in treating small-cell lung cancer that has come back, is resistant to treatment or has spread through the body. The main outcome that will be measured is how well the patients respond to the treatment. The study is taking place in the United...
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In a nutshell This trial is examining the effectiveness and safety of vicriviroc (VIC) plus pembrolizumab (Keytruda) in the treatment of advanced colorectal cancer. The main outcome to be measured is the tumor response to treatment. This trial is being conducted in the US and Canada. The details Colorectal cancer is the third most common...
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In a nutshell This study investigated the safety and effectiveness of a new chimeric antigen receptor (CAR) T cell therapy for relapsed or refractory (does not respond to treatment) multiple myeloma (MM). This study found that this cell therapy was effective, but it had significant side effects. Some background MM is a type of cancer of the...
Read MoreIn a nutshell This study will investigate the effectiveness of a new combination of chemotherapies: clarithromycin (Biaxin), lenalidomide (Revlimid) and dexamethasone (Decadron), for newly diagnosed multiple myeloma (MM). The main outcome that will be measured is survival without cancer worsening. This trial will take place in New York, the U.S....
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In a nutshell This study determined whether stereotactic body radiation therapy (SBRT) was more effective than standard radiotherapy in patients with inoperable non-small cell lung cancer. The study found that SBRT led to better survival outcomes for these patients, with minimal side effects. Some background Tumor removal by surgery is the standard of...
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In a nutshell This phase 1 trial is investigating the effectiveness and safety of a new T-cell therapy for relapsed or unresponsive lymphoma. The main outcome to be measured will be the side effects of treatment and long-term survival. This study is being conducted in Chapel Hill, North Carolina, United States. The details In cancer therapy,...
Read MoreIn a nutshell This trial aims to investigate a new cancer medicine called xentuzumab together with exemestane (Aromasin) and everolimus (Afinitor) in women who have breast cancer that has spread. The main outcome that will be measured is how long the patients go without cancer growing. The details Xentuzumab is a new medication that works...
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