This trial aims to find out if targeted radiotherapy on the breast in women with low-risk breast cancer after breast-conserving surgery will prevent the cancer from coming back. The main outcome that will be measured is how long it takes before the breast cancer comes back. The study is being conducted in Canada and the United States.
Regional (targeted) radiotherapy is often performed on the breast/chest area in women who have breast cancer. This may help prevent the cancer from coming back. However, in patients with low-risk breast cancer, this might not be necessary. This treatment can also have significant side effects.
This trial aims to find out if doing radiotherapy on the breast in women with low-risk breast cancer will prevent the cancer from coming back. The main outcome that will be measured is how long it takes before the breast cancer comes back.
Who are they looking for?
The study is looking to recruit 2140 patients who have had surgery for breast cancer. Patients have to have had, or be planning to have hormonal therapy and they must agree to use birth control.
Patients cannot be in the trial if they have previously had breast cancer in the other breast, or have any other type of disease which may interfere with the trial.
How will it work
This trial will consist of two groups. One group will have the whole breast undergo radiotherapy after surgery, or they will have no radiotherapy at all. The second group will have radiotherapy that is targeted at the lymph nodes in the area. The patients will be followed through time up to 9.5 years to see if the cancer comes back.