In a nutshell This phase 2 trial will investigate the safety of pembrolizumab (Keytruda) in combination with VRP-HER2 vaccination in HER2-positive breast cancer (BC). The main outcomes will be the response of the immune system, clinical response, and side effects. This trial will be taking place in North Carolina, the U.S. The...
Read MorePerformance status-1 – Slightly symptomatic Posts on Medivizor
Searching for patients to try a new treatment for multiple myeloma.
In a nutshell This study will investigate the effects of a new treatment, GSK2857916, in patients with multiple myeloma (MM). Overall response will be the main outcome measured. The details There are many treatment options for MM. However, some patients do not respond to treatments or relapse. New therapies are being developed for these patients....
Read MoreLooking for patients with metastatic colorectal cancer to test a new treatment
In a nutshell This trial is examining the effectiveness and safety of a combined treatment with pembrolizumab (Keytruda) and binimetinib (Mektovi). The main outcome to be measured is the tumor response to the treatment. This trial is recruiting in the United States and Canada. The details Colorectal cancer is the third most common cancer in the...
Read MoreSearching for patients with non-small cell lung cancer to trial a new anti-cancer drug
In a nutshell This trial is examining a new anti-cancer medication for non-small cell lung cancer called tislelizumab. The main outcome that will be measured is how long it takes for the cancer to start growing again. This study is recruiting across the United States. The details Non-small cell lung cancer (NSCLC) can be...
Read MoreLooking for patients with chronic lymphocytic leukemia to test acalabrutinib-obinutuzumab combination
In a nutshell This phase 2 trial is evaluating the effectiveness of acalabrutinib (Calquence) with or without obinutuzumab (Gazyva) for chronic lymphocytic leukemia (CLL). The main outcome to be measured will be the number of patients who have a complete disappearance of all signs of cancer. This study is being conducted in Phoenix, Arizona,...
Read MoreLooking for patients with small lymphocytic lymphoma to test acalabrutinib-obinutuzumab combination
In a nutshell This phase 2 trial is evaluating the effectiveness of acalabrutinib (Calquence) with or without obinutuzumab (Gazyva) for small lymphocytic lymphoma (SLL). The main outcome to be measured will be the number of patients who have a complete disappearance of all signs of cancer. This study is being conducted in Phoenix, Arizona, Jacksonville,...
Read MoreLooking for patients with multiple myeloma to compare 2 conditioning regimens before stem cell transplantation
In a nutshell This study is evaluating the effectiveness of melphalan (Alkeran) alone compared to BEAM chemotherapy (carmustine, etoposide, cytarabine, and melphalan) in patients with multiple myeloma before a stem cell transplant (SCT). The main outcome to be measured will be the number of patients who have complete disappearance of all signs of...
Read MoreSearching for patients with triple negative breast cancer to test a new medication
In a nutshell This phase 3 trial will investigate the safety and effectiveness of adagloxad simolenin (AGS)/OBI-821 in triple-negative breast cancer (TNBC). The main outcome will be a change in survival without invasive disease. The details Breast cancer (BC) is one of the most common cancers. BC treatment depends on the tumor type....
Read MoreLooking for patients with lung cancer to trial a new medication
In a nutshell This phase 3 trial will investigate the effectiveness of pembrolizumab (Keytruda) in non-small cell lung cancer (NSCLC). The main outcomes will be the rates of survival without any signs and symptoms of cancer and overall survival. The details NSCLC is usually treated with a combination of surgery to remove tumors and...
Read MoreSearching for patients with to try a new therapy for multiple myeloma.
In a nutshell This study will investigate the effectiveness of daratumumab (Darzalex) added to VR-d regime [bortezomib (Velcade), lenalidomide (Revlimid), and dexamethasone (Decadron)] versus VR-d alone in untreated multiple myeloma (MM). The development of minimal residual disease (MRD; a very small number of cancer cells remaining after treatment)...
Read MoreLooking for participants with advanced lung cancer to test a new cancer vaccine
In a nutshell This trial is examining the effectiveness of a new cancer vaccine. The main outcomes to be measured are cancer response and side effects. This trial is recruiting in New York and Tennessee, US. The details The standard treatment for most cancers is surgery and chemotherapy. However, chemotherapy has a limited effectiveness and a high...
Read MoreSearching for patients with early stage breast cancer to trial a new radiation treatment plan
In a nutshell The trial aims to investigate a new way of delivering radiation therapy in women with early-stage breast cancer. This will involve low doses of radiation therapy being aimed at the part of the breast where the tumor is or was. The main outcomes that will be measured are side effects and recurrence rate. This trial is recruiting in Missouri,...
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