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How effective is non-myeloablative chemotherapy after high-dose methotrexate-based treatment in patients with primary central nervous system lymphoma?

How effective is non-myeloablative chemotherapy after high-dose methotrexate-based treatment in patients with primary central nervous system lymphoma?

Posted by on Jun 1, 2022 in Non-Hodgkin lymphoma | 0 comments

In a nutshell This study evaluated the outcomes of patients with primary central nervous system lymphoma (PCNSL) on high-dose methotrexate (HD-MTX; Otrexup)-based chemotherapy followed by non-myeloablative consolidation therapy. The study showed that HD-MTX-based chemotherapy with non-myeloablative consolidation therapy is an alternative and...

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Does vitamin D supplementation affect ovarian reserve markers in women with infertility associated with diminished ovarian reserve?

Does vitamin D supplementation affect ovarian reserve markers in women with infertility associated with diminished ovarian reserve?

Posted by on Jun 1, 2022 in Infertility | 0 comments

In a nutshell This study evaluated the effects of vitamin D supplementation on ovarian reserve markers in women with infertility due to reduced ovarian reserves and vitamin D deficiency. The study showed possible beneficial effects on ovarian reserve markers with vitamin D supplementation in these women. Some background Ovarian reserve refers to the...

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Can disease flare be predicted following remission and treatment withdrawal in patients with early rheumatoid arthritis?

Can disease flare be predicted following remission and treatment withdrawal in patients with early rheumatoid arthritis?

Posted by on Jun 1, 2022 in Rheumatoid Arthritis | 0 comments

In a nutshell This study identified predictors of disease flare in patients with early, active rheumatoid arthritis (RA) that had stopped methotrexate (MTX; Otrexup) and/or abatacept (Orencia) treatment after clinical remission was achieved at 12 months. The data showed that patient function (HAQ-DI) and bone erosion based on magnetic resonance...

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Evaluating the effectiveness and safety of adding abiraterone acetate and prednisolone with or without enzalutamide to androgen-deprivation therapy in patients with high-risk non-metastatic prostate cancer.

Evaluating the effectiveness and safety of adding abiraterone acetate and prednisolone with or without enzalutamide to androgen-deprivation therapy in patients with high-risk non-metastatic prostate cancer.

Posted by on May 31, 2022 in Prostate cancer | 0 comments

In a nutshell The study evaluated the effectiveness and safety outcomes of adding abiraterone acetate (AA; Zytiga) and prednisolone (P; Deltasone) with or without enzalutamide (Xtandi) to androgen-deprivation therapy (ADT) in patients with high-risk non-metastatic prostate cancer (PC). The data showed that AAP added to ADT significantly improved survival...

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Evaluating the benefits of a more versus a less intensive blood pressure lowering treatment strategy in patients with hypertension.

Evaluating the benefits of a more versus a less intensive blood pressure lowering treatment strategy in patients with hypertension.

Posted by on May 31, 2022 in Hypertension | 0 comments

In a nutshell This study evaluated the benefits of a more versus a less intensive blood pressure (BP) lowering treatment strategy in patients with hypertension (high blood pressure). The data showed that a more intensive BP lowering treatment strategy significantly reduced the risks of stroke, heart failure, heart attacks, and cardiovascular death...

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Evaluating the effect of trimetazidine for the treatment of patients with ischemic heart disease who are not suitable for revascularization.

Evaluating the effect of trimetazidine for the treatment of patients with ischemic heart disease who are not suitable for revascularization.

Posted by on May 31, 2022 in Coronary artery disease | 0 comments

In a nutshell This study evaluated the effectiveness of trimetazidine (Vastarel) versus other anti-anginal drugs for the treatment of patients with ischemic heart disease (IHD) who are not suitable for revascularization. The data showed that trimetazidine improved walking time and angina attacks in these patients. Some background Coronary artery...

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Evaluating the long-term effectiveness and safety of device-aided therapies for the treatment of real-world patients with advanced Parkinson’s disease.

Evaluating the long-term effectiveness and safety of device-aided therapies for the treatment of real-world patients with advanced Parkinson’s disease.

Posted by on May 31, 2022 in Parkinson's Disease | 0 comments

In a nutshell This study evaluated the long-term effectiveness and safety of device-aided therapies (DATs) for the treatment of real-world patients with advanced Parkinson’s disease (PD). The data showed that in the long-term, DATs are well maintained among these patients. Some background Parkinson's disease (PD) is a disorder in which part...

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Evaluating the impact of mid-urethral sling surgery and bulk injection therapy on sexual function in women with stress urinary incontinence.

Evaluating the impact of mid-urethral sling surgery and bulk injection therapy on sexual function in women with stress urinary incontinence.

Posted by on May 31, 2022 in Urinary incontinence | 0 comments

In a nutshell This study evaluated the impact of mid-urethral sling (MUS) surgery and bulk injection (BI) therapy on sexual function in women with stress urinary incontinence (SUI). The study found that BI therapy and MUS surgery improved sexual function equally in sexually active women with SUI. Some background Stress urinary incontinence (SUI)...

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Can canagliflozin improve insulin resistance and internal fat tissue in patients with type 2 diabetes better than metformin?

Can canagliflozin improve insulin resistance and internal fat tissue in patients with type 2 diabetes better than metformin?

Posted by on May 31, 2022 in Diabetes mellitus | 0 comments

In a nutshell This study assessed the effects of canagliflozin (Invokana) therapy on body composition, glucose control, insulin resistance, and systemic (whole body) inflammation in patients with newly-diagnosed type 2 diabetes (T2D) compared to metformin (Glucophage). The data showed that canagliflozin therapy reduced visceral fat tissue, and...

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Does diabetes affect lower urinary tract symptoms in patients with benign prostatic hyperplasia?

Does diabetes affect lower urinary tract symptoms in patients with benign prostatic hyperplasia?

Posted by on May 31, 2022 in Benign prostatic hyperplasia | 0 comments

In a nutshell This study reviewed the effect of diabetes on lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia (BPH). The data suggested that LUTS were increased in patients with BPH that had diabetes compared to patients without diabetes. Some background Men above 50 years of age frequently experience LUTS due to benign...

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Does diabetes affect lower urinary tract symptoms in patients with benign prostatic hyperplasia?

Does diabetes affect lower urinary tract symptoms in patients with benign prostatic hyperplasia?

Posted by on May 31, 2022 in Diabetes mellitus | 0 comments

In a nutshell This study reviewed the effect of diabetes on lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia (BPH). The data suggested that LUTS were increased in patients with BPH that had diabetes compared to patients without diabetes. Some background Men above 50 years of age frequently experience LUTS due to...

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Can a low-carbohydrate diet affect insulin-resistant lipoprotein metabolism?

Can a low-carbohydrate diet affect insulin-resistant lipoprotein metabolism?

Posted by on May 31, 2022 in Diabetes mellitus | 0 comments

In a nutshell This study determined the effect of varying carbohydrate and saturated fat dietary contents on cardiovascular disease (CVD) risk factors during weight-loss maintenance. The authors concluded that restriction of carbohydrates provided improved insulin resistance on lipoprotein metabolism, without unwanted side effects on low-density...

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