In a nutshell The main objective of this study was to determine the impact of nocturnal hypoglycemia on sleep patterns in patients with type 2 diabetes. The authors concluded that nocturnal hypoglycemia caused a decrease in a patient's ability to wake up and respond to episodes of low blood sugar levels. Some background Nocturnal hypoglycemia...
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In a nutshell The main objective of this analysis was to determine the benefit of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) compared to insulin treatment in patients with type 2 diabetes who were receiving treatment with oral glucose-lowering medications (OGLM – used to produce insulin in patients who cannot produce enough by...
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In a nutshell The authors aimed to determine the safety and efficacy of saxagliptin (Onglyza) as an add-on treatment in patients with type 2 diabetes already receiving treatment with dapagliflozin (Farxiga) and metformin (Glucophage). The authors concluded that using saxagliptin as an add-on treatment for 52 weeks resulted in improvements in blood...
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In a nutshell The authors aimed to determine the effect and safety of linagliptin (Tradjenta) in patients with type 2 diabetes with liver disease. The authors concluded that linagliptin is an effective and safe treatment in patients with type 2 diabetes and liver disease. Some background Diabetes raises the risk of non-alcohol...
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In a nutshell This study examined the effects of saxagliptin (Onglyza) in patients with type 2 diabetes and impaired kidney function. The study concluded that saxagliptin had similar effects regardless of kidney function, but did increase the risk of hospitalization for heart failure. Some background High blood glucose (sugar) levels can,...
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In a nutshell This study compared the outcomes of bariatric surgery between patients with early onset (before age 40) and late onset (after age 40) type 2 diabetes. They found that bariatric surgery had more successful outcomes in those with early onset type 2 diabetes. Some background As the number of patients with type 2 diabetes (T2D) continues...
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In a nutshell This review examined the risk of mortality associated with sulfonylureas in patients with type 2 diabetes. The authors concluded that sulfonylureas do not increase the risk of mortality or cardiovascular mortality. Some background Patients with type 2 diabetes (T2D) may be treated with medication to reduce blood glucose (sugar)...
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In a nutshell This study examined whether alogliptin is safe and effective for the treatment of elderly patients with type 2 diabetes (T2D).The authors concluded that alogliptin is safe and effective for elderly T2D patients and does not lead to weight gain. Some background Patients with T2D may be treated with anti-diabetic...
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In a nutshell This paper studied the heart-related safety and efficacy of saxagliptin (Onglyza) in patients with type 2 diabetes. The authors concluded that saxagliptin did not improve the risk of cardiovascular disease. Some background Patients with type 2 diabetes mellitus have elevated levels of glucose (sugar) in their blood. High...
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In a nutshell This study examined whether empagliflozin (Jardiance) reduces the risk of mortality in type 2 diabetes (T2D) patients. The authors concluded that T2D patients treated with empagliflozin have a lower risk of mortality. Some background Cardiovascular disease (CVD) is the narrowing or blockage of blood vessels and...
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In a nutshell This study aimed to determine the effect of sitagliptin and dextromethorphan on blood glucose levels. Some background Patients with type 2 diabetes (T2D) initially produce insulin (hormone which lowers blood glucose levels). However, insulin fails to work in the body. Drugs such as metformin...
Read MoreIn a nutshell This study examined whether liraglutide (Victoza) improves the function of the insulin-producing cells in type 2 diabetes. Some background Type 2 diabetes is a progressive disease. As it progresses patients increasingly lose beta cell function (the cells that produce insulin, the hormone needed to break down glucose,...
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