In a nutshell This study compared additional treatment options for patients with uncontrolled type 2 diabetes (T2D) currently taking basal insulin and other oral anti-diabetic drugs (OADs). They concluded that lixisenatide (Lyxumia and Adlyxin) may be a preferable option to insulin with meals. Some background One treatment option for T2D is...
Read MoreDiabetes medication(s)-Insulin Posts on Medivizor
Is dapagliflozin a good addition to liraglutide and insulin therapy for type 1 diabetes?
In a nutshell This study investigated whether adding dapagliflozin (Farxiga/Forxiga) to liraglutide (Victoza) and insulin therapy would improve blood glucose control and promote weight loss in patients with type 1 diabetes (T1D). Improved blood glucose control and weight loss was recorded, however increased ketosis (raised ketone acids in the blood)...
Read MoreThe benefits of combining metformin with insulin
In a nutshell This study examined whether metformin can reduce the risk of mortality, cardiovascular (heart and blood vessel) events, and cancer in patients with type 2 diabetes when combined with insulin. The authors concluded that a combination of insulin and metformin reduces the mortality and cardiovascular risk. Some background Insulin...
Read MoreCan GLP-1 receptor agonists improve variation in blood glucose levels?
In a nutshell This study examined whether glucagon-like peptide-1 receptor agonists can reduce glucose variability in insulin-dependent patients with type 2 diabetes. The authors concluded that glucagon-like peptide-1 receptor agonists reduce glucose variability and weight while maintaining similar HbA1c levels. Some background HbA1c is a measure...
Read MoreHigh blood pressure during severe hypoglycemic events can result in reduced kidney function
In a nutshell This study investigated whether type 2 diabetes patients were at increased risk of kidney damage if their blood pressure surged during hypoglycemic (dangerously low levels of glucose) events. The study concluded that kidney function did worsen in patients whose blood pressure surged during severe hypoglycemic events. Some...
Read MoreLow calorie diet in obese patients with type 2 diabetes
In a nutshell This study examined whether a low calorie diet is effective in obese patients with type 2 diabetes receiving different insulin treatments. The authors concluded that a low calorie diet leads to weight reduction and improves control of blood glucose levels regardless of insulin treatment. Some background Obese patients with type 2...
Read MoreCanagliflozin – an add-on to insulin therapy in type 1 diabetes?
In a nutshell This study investigated the safety and effectiveness of canagliflozin (Invokana) as an add-on to insulin therapy in type 1 diabetes. The study concluded that canagliflozin caused a decrease in HbA1c, body weight and insulin dose in adults with type 1 diabetes. Some background The standard treatment option for type 1 diabetes is...
Read MoreNew faster acting insulin aspart
In a nutshell This study compared the effects of two types of insulin – the currently used fast-acting insulin aspart (NovoLOG/NovoRapid) and a new faster-acting insulin aspart. The study concluded that the faster-acting insulin aspart had a faster blood glucose lowering effect. Some background In individuals without diabetes, the...
Read MoreGlucagon: Treating hypoglycemia without the carbs?
In a nutshell This study investigated the effects of glucagon injection on insulin-induced hypoglycemia. The study concluded that glucagon restored blood sugars levels after mild hypoglycemia. Some background Hypoglycemia (very low blood sugar levels) is one of the major barriers of good blood sugar control. It is associated with a range of...
Read MoreDual-peroxisome agonists: Early-phase trial results of aleglitazar
In a nutshell This early-phase trial examined whether aleglitazar could be of benefit for the treatment of type 2 diabetes. The authors concluded that aleglitazar improves both blood glucose and cholesterol levels among diabetic patients. As of 2013, all further drug development of aleglitazar was halted...
Read MoreNew manufacturing method for long-acting insulin
In a nutshell The study investigated the safety and effectiveness of LY2963016 insulin glargine (LY IGlar). It was concluded that LY IGlar is as effective and well-tolerated as current standard insulin glargine (Lantus). Some background Insulin glargine is a long-acting form of insulin. Long-acting insulin is often used to provide stable blood...
Read MoreInsulin inhalers – the future of diabetes care?
In a nutshell This study compared the safety and effectiveness of inhaled insulin with injected insulin. This study concluded that inhaled insulin was as effective as injected, with less incidence of very low blood glucose levels, but with higher incidence of cough. Some background Currently, the typical treatment for type 1 diabetes (T1D), and...
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