In a nutshell This trial will evaluate the safety and effectiveness of the Hybrid Closed Loop (HCL) system in adult and pediatric patients with type 1 diabetes. The primary outcome of this study will be a change in HbA1c levels (average blood glucose over 3 months). The details HCL systems are a diabetes management strategy. They are composed of...
Read MoreDiabetes medication(s)-Insulin Posts on Medivizor
Glyburide: a safe and effective medication for the treatment of gestational diabetes?
In a nutshell This study investigated if glyburide (Glynase) was safer and more effective than insulin in patients with gestational diabetes. They found that glyburide was associated with an increased risk of neonatal hypoglycemia (low blood sugar) but was well tolerated overall. Some background Gestational diabetes mellitus (GDM)...
Read MoreCan a bionic pancreas effectively provide day-to-day glycemic control in patients with type 1 diabetes?
In a nutshell This study investigated if a bionic pancreas, that releases insulin and glucagon (bihormonal), could improve glycemic (blood sugar) control in patients with type 1 diabetes. They found that the bionic pancreas was more effective than a conventional insulin pump in monitoring and managing glycemia in these patients. Some background...
Read MoreDoes IDegLira improve outcomes in patients with uncontrolled type 2 diabetes?
In a nutshell This study looked at the effects of IDegLira, a combination insulin drug, on outcomes in patients with uncontrolled type 2 diabetes. They found that IDegLira improved glycemic (blood sugar) control and aided weight loss in these patients. Some background The treatment of type 2 diabetes is to achieve glycemic control. This can slow...
Read MoreThe closed-loop insulin system during pregnancy
In a nutshell This study examined whether closed-loop or “automated” delivery of insulin would be a suitable treatment for pregnant women with type-1 diabetes. The authors concluded that the closed-loop therapy successfully controlled blood-sugar levels during pregnancy, labor and delivery. Some background Type-1 diabetes (T1D) occurs...
Read MoreContinuous glucose monitoring improves glycemic control in patients with type 1 diabetes
In a nutshell This study investigated the effect of continuous glucose monitoring (CGM) in managing blood sugar levels in patients with type 1 diabetes treated with multiple daily insulin injections. They found CGM resulted in a clinically meaningful improvement in glycemic (blood sugar) control. Some background Glycemic control is critical for...
Read MoreInsulin glargine 300 u/ML is associated with long-term glycemic control and lower rates of hypoglycemia
In a nutshell This study looked at the safety and efficacy of long-acting insulin drug, Gla-300 in maintaining glycemic (blood sugar) control in adults with type 1 diabetes. This study concluded that patients taking Gla-300 had better glycemic control than those using Gla-100, a lower dose of the same basal insulin glargine. Some background...
Read MoreLower blood pressure is associated with reduced risk of kidney disease in type 1 diabetes
In a nutshell This study examined the association between blood pressure (BP) and the risk of kidney disease in patients with type 1 diabetes. They found that lower BP was associated with a lower risk of kidney complications. Some background It is recommended that adults with diabetes maintain a BP below 140/90 mmHg. This has been determined...
Read MoreImplantable continuous glucose sensor found to be accurate
In a nutshell This study investigated the safety and accuracy of a new implantable continuous glucose monitoring (CGM) sensor. It found that the device was accurate and safe. Some background CGM systems provide real-time information on glucose levels and reduce the need for fingerstick testing. In CGM systems glucose is measured by a sensor placed...
Read MoreArtificial pancreas effective in regulating glucose in patients with well-controlled type 1 diabetes
In a nutshell This study compared a new method of insulin delivery, a hybrid closed-loop system, with standard insulin pumps in patients with type 1 diabetes (T1D). It was found that the time spent at the desired glucose concentration was improved with the closed-loop system. Some background A traditional insulin pump is a small device that...
Read MoreShort and long-acting GLP-1 receptor agonists as an add-on treatment in type 2 diabetes
In a nutshell The main objective of this analysis was to determine the benefit of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) compared to insulin treatment in patients with type 2 diabetes who were receiving treatment with oral glucose-lowering medications (OGLM – used to produce insulin in patients who cannot produce enough by...
Read MoreLooking for type 1 diabetes patients to undergo islet cell transplantation into the stomach lining
In a nutshell The main objective of this trial is to determine the safety and effectiveness of transplanting islet cells (pancreas cells that produce insulin) onto the omentum (skin that forms the stomach lining and connects the stomach to other abdominal organs). The main outcome will be the number of patients who achieve normal blood glucose levels...
Read More
