In a nutshell This study will investigate the effects of high-pressure oxygen on the transplant of umbilical cord blood stem cells in patients with blood cancers. The main outcome that will be measured is the time it takes for white blood cells to recover after treatment. This trial is recruiting in New York, US. The details Stem cell transplant (SCT)...
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Searching for participants with leukemia and lymphoma to try a new treatment before stem cell transplantation
In a nutshell This study will investigate the effects of high-pressure oxygen on the transplant of umbilical cord blood stem cells in patients with blood cancers. The main outcome that will be measured is the time it takes for white blood cells to recover after treatment. This trial is recruiting in New York, US. The details Stem cell transplant (SCT)...
Read MoreLooking for patients with advanced triple negative breast cancer to test a new drug
In a nutshell This phase 1 study will investigate the dose range and effectiveness of an experimental drug, XmAb23104, in the treatment of advanced breast cancer and other solid tumors. The main outcome will be the safety and tolerability of XmAb23104. This trial is recruiting in Georgia, Texas, and Virginia, the United States. The details...
Read MoreSearching for patients with advanced triple negative breast cancer to trial a new treatment into the tumor
In a nutshell This phase 2 study will investigate Tavokinogene Telseplasmid Electroporation (TTE) in combination with pembrolizumab (Keytruda) in advanced or not suitable for surgery triple-negative breast cancer (TNBC). The main outcome will be the objective response rate (ORR). This trial is recruiting in the United States and...
Read MoreLooking for patients with Ph+ or BCR-ABL+ acute lymphoblastic leukemia to test a treatment combination
In a nutshell This phase 2 trial is evaluating the effectiveness of ponatinib (Iclusig) plus chemotherapy for patients with acute lymphoblastic leukemia (ALL) that is positive for the Philadelphia chromosome (Ph+) or the BCR-ABL gene (BCR-ABL+). The main outcome to be measured will be the number of patients who respond to treatment. This study is...
Read MoreLooking for older patients with acute myeloid leukemia to test a new treatment combination
In a nutshell This study is evaluating how well CPI-613 plus chemotherapy works in older patients with acute myeloid leukemia (AML) that has come back or stopped responding to treatment. The main outcome to be measured will be the number of patients who have a complete disappearance of all signs of cancer. This trial is taking place across the United...
Read MoreSearching for patients with lymphoma or leukemia to test T-cell therapy after stem cell transplantation
In a nutshell This phase 2 trial is evaluating how well CD8+ memory T-cell therapy works in patients with leukemia or lymphoma after a stem cell transplant (SCT). The main outcome to be measured will be the number of patients who have full chimerism (donor cells work completely and only donor cells can be identified after transplant) after therapy. This...
Read MoreSearching for patients with lymphoma or leukemia to test T-cell therapy after stem cell transplantation
In a nutshell This phase 2 trial is evaluating how well CD8+ memory T-cell therapy works in patients with leukemia or lymphoma after a stem cell transplant (SCT). The main outcome to be measured will be the number of patients who have full chimerism (donor cells work completely and only donor cells can be identified after transplant) after therapy. This...
Read MoreLooking for patients with estrogen receptor-positive breast cancer to test a new treatment combination
In a nutshell This phase 2 trial will evaluate the safety and effectiveness of ribociclib (Kisqali) combined with hormonal therapy in patients with estrogen receptor-positive (ER+) breast cancer (BC). The main outcome will be the number of patients that complete 1 year of treatment and survival without signs of cancer. The trial will...
Read MoreSearching for patients with early-stage HER2+ breast cancer to trial a new treatment regime
In a nutshell This study will examine how safe and effective the medication atezolizumab (Tecentriq) is in combination with other anti-cancer medicines for treating early stage HER2+ breast cancer. The main outcome that will be measured is how many patients completely respond to treatment, with no trace of the cancer remaining. The details...
Read MoreSearching for patients with relapsed or unresponsive follicular lymphoma to trial a new drug
In a nutshell This trial will evaluate the effects of a new treatment parsaclisib (INCB050465) in relapsed or unresponsive follicular lymphoma (FL). Response rate, survival, and side effects will be the main outcomes measured. The details Many patients are cured with treatments for follicular lymphoma (FL). Some, however, lose response to therapy...
Read MoreSearching for patients with HIV-positive lymphoma to test EPOCH-R chemotherapy
In a nutshell This study is evaluating the effectiveness of EPOCH-R chemotherapy for patients with non-Hodgkin's lymphoma (NHL) who are HIV-positive. The main outcome to be measured will be survival without cancer growing or spreading. This study is recruiting in Bethesda, Maryland, United States. The details Patients with NHL who are...
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