In a nutshell This study looked at the use of specific T-cells to treat acute lymphoblastic leukemia. Researchers found that using these cells was effective in the treatment of these patients. Some background Acute lymphoblastic leukemia (ALL) is a type of cancer of the bone marrow. This can lead to abnormal cells in the immune system. It is often...
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Is blinatumomab safe and effective in the treatment of ALL?
In a nutshell This study looked at the safety and effectiveness of blinatumomab (Blincyto) in the treatment of unresponsive acute lymphoblastic leukemia (ALL). Researchers found that blinatumomab was safe and effective in the treatment of these patients. Some background Acute lymphoblastic leukemia is a type of cancer of the bone marrow. This can lead...
Read MoreIs regorafenib a safe option for the treatment of metastatic colorectal cancer?
In a nutshell This study investigated the effectiveness and safety of regorafenib (Stivarga) to treat patients with metastatic (spread to other parts of the body) colorectal cancer (mCRC) that progressed after initial treatment. Researchers suggested that regorafenib is a safe option to treat these patients. Some background The standard treatment...
Read MoreEvaluating survival outcomes after brentuximab vedotin treatment for relapsed or refractory Hodgkin’s lymphoma
In a nutshell This study evaluated the impact of brentuximab vedotin (Adcetris) on the survival of patients with relapsed or refractory (does not respond to treatment) classical Hodgkin’s lymphoma (cHL). This study concluded that brentuximab vedotin significantly improved survival in these patients. Some background Patients with cHL who...
Read MoreEvaluating the long-term outcomes of brentuximab vedotin after stem cell transplantation for classical Hodgkin’s lymphoma
In a nutshell This study evaluated the long-term survival and safety of brentuximab vedotin (Adcetris) treatment for patients with classical Hodgkin’s lymphoma (cHL) after autologous stem cell transplantation (auto-SCT; patient's own healthy stem cells are retrieved and then returned into the body after cancer has been removed with chemotherapy...
Read MoreEvaluating lenalidomide plus everolimus for relapsed or refractory lymphoma
In a nutshell This study investigated the effectiveness and safety of lenalidomide (Revlimid) plus everolimus (Afinitor) in pretreated patients with relapsed (recurrent) or refractory (does not respond to treatment) lymphoma. This study concluded that this combination was well-tolerated and showed promising effectiveness in these patients. Some...
Read MoreThe safety of elotuzumab, lenalidomide and dexamethasone in unresponsive multiple myeloma.
In a nutshell This paper compared the safety and effectiveness of elotuzumab (Empliciti) plus lenalidomide (Revlimid) and dexamethasone (Decadron) with lenalidomide and dexamethasone in unresponsive multiple myeloma. It was found that elotuzumab plus lenalidomide and dexamethasone was more effective than lenalidomide and dexamethasone alone. Some...
Read MoreComparing duvelisib and ofatumumab in chronic lymphocytic leukemia
In a nutshell This study aimed to compare the safety and effectiveness of duvelisib (Copiktra) and ofatumumab (Arzerra) in patients with relapsed or refractory chronic lymphocytic leukemia. This study concluded that duvelisib was an effective treatment option for these patients. Some background Chronic lymphocytic leukemia (CLL) is the most common...
Read MoreIs chemotherapy before transplantation safe and effective in AML?
In a nutshell The study looked at the safety and effectiveness of combining different chemotherapy drugs followed by stem-cell transplant for the treatment of unresponsive acute myeloid leukemia (AML). Researchers found that this method was safe and effective in the patients studied. Some background Acute myeloid leukemia is a cancer of the bone...
Read MoreCan prednisone be replaced with dexamethasone in patients with prostate cancer treated with abiraterone acetate?
In a nutshell This study aimed to investigate the use of dexamethasone, instead of prednisone, used with abiraterone acetate (Zytiga) for patients with metastatic castration-resistant prostate cancer (mCRPC). This study found that prednisone to dexamethasone switch can benefit some patients with mCRPC. Some background Androgen deprivation therapy...
Read MoreEvaluating BendaEAM chemotherapy before stem cell transplantation for relapsed lymphoma
In a nutshell This study evaluated the effectiveness and safety of the BendaEAM (bendamustine, etoposide, cytarabine, melphalan) in patients with lymphoma undergoing autologous stem cell transplantation (auto-SCT). This study concluded that BendaEAM is a feasible option for these patients, with minimal side effects. Some background High-dose...
Read MoreEvaluating venetoclax monotherapy for relapsed or refractory mantle cell lymphoma
In a nutshell This study evaluated the effectiveness and safety of venetoclax (Venclexta) monotherapy (single-agent treatment) in patients with relapsed (cancer recurrence) or refractory (does not respond to initial treatment) mantle cell lymphoma (MCL). This study concluded that venetoclax monotherapy is promising, with minimal side effects. Some...
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