In a nutshell In this review, the authors look at the most common adverse events related to ibrutinib and idelalisib, B-cell inhibitors. The study concluded that both ibrutinib and idelalisib are effective at treating B-cell cancers, and the side effects are within a normal range compared to other similar treatments. Some...
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In a nutshell This paper studied the effect of lymphodepletion chemotherapy and CAR-T cell infusion in patients with chronic lymphocytic leukemia who did not respond to ibrutinib (Imbruvica) therapy. This was found to be a highly effective treatment. Some background Chronic lymphocytic leukemia (CLL) is a cancer of the blood forming cells....
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In a nutshell This phase 3 clinical trial will test the effectiveness of a lenalidomide (Revlimid) and rituximab (Rituxan) maintenance therapy followed by rituximab and lenalidomide or rituximab only in treating relapsed follicular, marginal zone, or mantle cell lymphoma. The primary outcome will be measured by the time to disease progression....
Read MoreIn a nutshell This phase 2 clinical trial will test the effectiveness of TGR-1202 in patients with relapsed or refractory follicular lymphoma. The primary outcome will be measured by the overall response rate. This trial is being conducted at the Columbia University Medical Center in New York, New York. The details TGR-1202 (umbralisib)...
Read MoreIn a nutshell This phase 2 clinical trial will test the effectiveness and safety of ublituximab (TG-1101) and TGR-1202 with or without bendamustine (Treanda), as well as TGR-1202 alone in treating patients with relapsed or refractory non-Hodgkin’s lymphoma. The primary outcome will be measured by the overall response. The details...
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In a nutshell This trial looked at therapy that activates the immune system to kill cancerous tumors in patients with extensive stage small cell lung cancer (ES-CLC). The authors concluded pembrolizumab (Keytruda) is tolerable and a promising treatment for patients with heavily treated ES-SCLC. Some background Extensive-stage small cell lung...
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In a nutshell This phase 2 clinical trial will test the effectiveness of a combination of panobinostat (Farydak), gemcitabine (Gemzar), busulfan (Busulfex), and melphalan (Alkeran), and a stem cell transplant in treating multiple myeloma. The primary outcome will be measured by the time until the disease progresses. This trial is being conducted in...
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In a nutshell This phase 2 clinical trial will test the effectiveness of axicabtagene ciloleucel (KTE-C19) in treating relapsed or refractory (unresponsive to treatment) indolent non-Hodgkin’s lymphoma (iNHL). The primary outcome will be measured by the response rate. The details Axicabtagene ciloleucel is a chimeric antigen...
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In a nutshell This phase 1 clinical trial will test the safety of JCAR017 CAR T-cells in treating patients with relapsed or refractory (unresponsive to treatment) B-cell non-Hodgkin’s lymphoma. The primary outcome with be measured by adverse (negative) side effects, maximum dosage, response rate, and concentration of JCAR017. The...
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In a nutshell This study aimed to investigate the outcomes of hematopoietic cell transplantation for primary refractory acute lymphoblastic leukemia. This study concluded that hematopoietic cell transplantation is of benefit to patients with primary refractory acute lymphoblastic leukemia. Some background Acute lymphoblastic leukemia (ALL)...
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In a nutshell This paper reviewed advances in treatment options for relapsed and refractory chronic lymphocytic leukemia. Some background Chronic lymphocytic leukemia (CLL) is a cancer of the blood and blood forming cells. Despite a good response to initial therapy, most patients relapse and require further treatment. Some patients may stop...
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In a nutshell This study looked at the effect of remaining leukemia cells (present in bone marrow during remission) on stem cell transplant outcomes in acute myeloid leukemia patients. The study concluded that the presence of leukemia cells prior to stem cell transplantation has a negative effect on patient outcomes. Some background Adult...
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