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Posted by on Sep 4, 2017 in Lung cancer | 0 comments

In a nutshell

This trial looked at therapy that activates the immune system to kill cancerous tumors in patients with extensive stage small cell lung cancer (ES-CLC). The authors concluded pembrolizumab (Keytruda) is tolerable and a promising treatment for patients with heavily treated ES-SCLC.

Some background

Extensive-stage small cell lung cancer patients have poor survival rates because the cancer usually progresses past first-line chemotherapy treatment. Therefore more effective treatments are needed. Immune checkpoint inhibitors including pembrolizumab work by blocking a protein called PD-L1 present on tumors. This results in activating the immune system to kill the tumor. Pembrolizumab has been shown to be effective for other cancers including other types of lung cancers. Whether it would be an effective treatment for ES-SCLC remains to be seen.

Methods & findings

This trial looked at the effectiveness and safety of pembrolizumab at treating patients with ES-SCLC with PD-L1 on tumors.

24 patients were included in this trial. These patients had all progressed past previous treatment for ES-SCLC. Patients were followed for an average of 9.8 months.

All patients had side effects. The most common were physical weakness (7 patients), fatigue (7 patients) and cough (6 patients). Other side effects included joint pain, diarrhea, insomnia, and rash. 

The objective response rate (percent of patients with tumor reduction or stable disease) was 33.3%. The average progression free survival (PFS, time from beginning trial until disease progression) was 1.9 months. The average PFS rate at 2 years post treatment was 23.8%. Average overall survival (OS, time from beginning trial until death from any cause) was 9.7 months. OS at 1 year after treatment was 37.7%.

The bottom line

The authors concluded that the toxicity levels associated with pembrolizumab were the same as previously reported levels. They also suggested the pembrolizumab is a promising treatment for patients with ES-SCLC that has progressed past initial treatments.

The fine print

This study was funded by manufacturers of pembrolizumab.

Published By :

Journal of clinical oncology

Date :

Aug 16, 2017

Original Title :

Pembrolizumab in Patients With Extensive-Stage Small-Cell Lung Cancer: Results From the Phase Ib KEYNOTE-028 Study.

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