In a nutshell This phase 3 clinical trial compared the safety and efficacy of two different combination treatments in women with early stage breast cancer: anastrozole (Arimidex) plus goserelin (Zoladex) versus tamoxifen (Nolvadex) plus goserelin. Some background An estrogen-receptor positive (ER+) breast cancer requires estrogen (the primary...
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Predicting residual or recurrent disease in patients with invasive colorectal adenocarcinoma developed from colorectal adenoma treated by endoscopy?
In a nutshell The present study evaluated factors associated with residual or recurrent disease in patients with colorectal adenocarcinomas developed from adenomas initially treated endoscopically. Some background A colorectal adenoma is a benign (non-cancerous) abnormal growth in the inner lining of the large intestine (colon and rectum) also...
Read MoreNutrition and physical activity guidelines for cancer survivors
In a nutshell This article outlines current guidelines regarding nutrition and physical activity for cancer survivors. Some background A cancer survivor is anyone diagnosed with cancer (cured or currently undergoing treatment). Environmental and dietary factors play a major role in cancer development. Adequate nutrition and regular physical...
Read MoreThe cancer rate among patients who were treated surgically for polyps that were impossible to remove endoscopically
In a nutshell This study aimed to determine the rate of cancer cases in patients with polyps that were removed surgically. Factors that predict the presence of cancer in these polyps were also investigated. The results confirm the fact that the best therapeutic option for polyps that cannot be removed endoscopically is radical surgery. Some background...
Read MoreSurgery versus endoscopic resection for malignant colorectal polyps
In a nutshell The present study compared outcomes of two treatment methods for patients with malignant colorectal polyps (MCP): endoscopic versus surgical management. Some background Most colorectal cancers develop from a malignant (cancerous) polyp, an abnormal growth on the inner surface of the large intestine. When a polyp is found, the only...
Read MoreSurgical options for the management of cancerous colonic polyps: surgery versus colonoscopic removal
In a nutshell The present study compared the results of two surgical techniques for the removal of cancerous colonic polyps: surgical resection versus colonoscopic polypectomy. Some background Most colorectal cancers develop from a malignant (cancerous) polyp, an abnormal growth on the inner surface of the large intestine. When a polyp is...
Read MoreSurveillance colonoscopy is performed early in patients who undergo curative surgery for colorectal cancer
In a nutshell This article evaluated how surveillance colonoscopies (SC) were used in colorectal cancer patients previously treated with surgery. The main finding was that many patients who had curative surgery (complete removal of the cancer) underwent SC more often than recommended by the guidelines. Some background Patients who undergo curative...
Read MoreTowards guidelines to prevent colorectal cancer recurrence
This article presents results of recent studies concerning the interplay between the body's chemistry and behavioral factors that influence colorectal cancer (CRC) recurrence. Recent advances in CRC treatment have produced new and promising biological treatments. However, tumors sometimes have unique features that render many of these therapies...
Read MoreThe impact of radiotherapy protocol on quality of life in patients with operable rectal cancer
In a nutshell This article evaluated the long-term quality of life of patients with rectal cancer, treated with either a short course of radiation before surgery, or postoperative chemo-radiation. Patients treated with pre-operative radiation reported worse sexual- and bowel-related functional outcomes. Some background In patients with...
Read MoreSugar-rich foods and colorectal cancer recurrence
In a nutshell This study investigated whether diets rich in carbohydrates influence recurrence rates in patients treated for colorectal cancer. The main finding was that a higher glycemic (sugar) load and carbohydrate intake were associated with a greater risk of cancer recurrence. Some background Dietary factors, as well as body...
Read MorePersonalizing breast cancer treatment based on the genetic “finger-print” of the tumor
This article discusses how tests such as the Oncotype DX or Mammaprint can be used to design individual treatment plans for patients with breast cancer. Patients with stage I and stage II breast cancer are treated similarly. Following surgical removal of a breast tumor, systemic (body-wide) treatment is often used. This secondary treatment is...
Read MoreCore-needle biopsy may often result in understaging of breast cancer
In a nutshell This study (2011) addressed the issue of understaging of invasive breast cancer using core-needle biopsy (CNB). Main findings: in this analysis of trials, about one in four diagnoses of ductal carcinomas in situ (DCIS) at CNB represented understaged invasive breast cancer. Some background CNB is a diagnostic procedure in which cells...
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