In a nutshell The present study compared the effectiveness of two kinds of hormonal therapy in advanced prostate cancer (cancer that has spread beyond the prostate gland). These are intermittent hormonal therapy (IHT) and continuous androgen-deprivation therapy (ADT). In this study, IHT was similar to ADT in terms of survival, but showed better quality...
Read MoreCurrent PSA level-20 or above Posts on Medivizor
Novel Therapies for Castration-Resistant Prostate Cancer
In a nutshell The present article reviews new and prospective treatments for castration-resistant prostate cancer (CRPC). Sipuleucel-T, Cabazitaxel, Denosumab and Abiraterone are novel therapies approved in the last few years for CRPC, while several other therapeutic agents such as MDV3100, Alpharadin and...
Read MoreNon-cancerous cells in the prostate contribute to the aquired tumor resistance to chemotherapy
Regretfully, metastatic forms of prostate cancer (spread to distant sites via the blood system) treated with chemotherapy often acquire resistance to the drug, partially due to the repetitive nature of treatment. Resistance leads to tumor progression and treatment failure. This scientific article proposes a novel therapeutic target named WNT16B that...
Read MoreComparing the safety of three different radiotherapy regimens: a clinical trial
In a nutshell This study evaluated the safety of two regimens of external beam radiation – short, high-dose radiotherapy – compared with the standard radiotherapy protocol. There were no substantial differences in side effects between the conventional and experimental radiotherapy regimens. Some background Prostate cancer which...
Read MoreEvaluating survival rates in patients with prostate cancer treated with low-dose-rate brachytherapy
In a nutshell The present study evaluated survival rates in patients with prostate cancer (PC) treated with Low-dose-rate prostate brachytherapy (LDR-PB). The main findings were that LDR-PB alone or combined with hormone therapy offers excellent survival in PC patients. Some background Prostate cancer is the most common type of cancer in men....
Read MoreExperimental drug – Enzalutamide – moderately increases survival in patients with advanced prostate cancer
In a nutshell This clinical trial evaluated the survival benefits of a drug named Enzalutamide (Xtandi) for patients with non-responsive (refractory) advanced prostate cancer previously treated with chemotherapy. Main findings: Enzalutamide prolonged survival by approximately 5 months and reduced the risk of death by 37%. Some background The...
Read MoreDenosumab: decrease in spread of bone cancer in men with prostate cancer (not responsive to hormone therapy & surgery)
In a nutshell The present study assessed the efficiency of a drug named Denosumab in delaying the spread of prostate cancer to the bone in men with resistant prostate cancer (not responding to hormone therapy and surgery). The results show that the drug tested delayed bone involvement by few months. Some background Bone metastases are...
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