In a nutshell This study evaluated the long-term outcomes of patients with advanced (stage 3 – 4) non-Hodgkin’s lymphoma (NHL) who received radioimmunotherapy before allogeneic stem cell transplantation (alloSCT). This study concluded that this treatment regimen improved survival in most of these patients. Some background AlloSCT involves...
Read MoreIn a nutshell This study is investigating the effectiveness of brentuximab vedotin (Adcetris) and nivolumab (Opdivo) in early-stage Hodgkin lymphoma (HL). The main outcome that will be measured will be survival without cancer worsening after 18 months. The details There are many different treatments for HL. Each treatment or combination of...
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In a nutshell This study looked at the safety and effectiveness of CT-P10 (Truxima) compared to rituximab (Rituxan) in the treatment of follicular lymphoma. Researchers found that CT-P10 had similar safety and effectiveness as rituximab in these patients. Some background Lymphoma is a cancer of the immune system. It is often treated with drugs...
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In a nutshell This study evaluated the safety and effectiveness of a new targeted therapy (INCB040093) with or without itacitinib in patients with relapsed or refractory (does not respond to treatment) lymphoma. This study concluded that this new agent was well-tolerated and showed promising effectiveness in these patients. Some background...
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In a nutshell This study evaluated the safety and effectiveness of brentuximab vedotin (Adcetris) plus gemcitabine (Gemzar) in children and young adults with relapsed or refractory (does not respond to treatment) Hodgkin’s lymphoma (HL). This study concluded that this combination is safe and shows promising effectiveness in these...
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In a nutshell This study evaluated the outcomes of patients with localized (cancer has not spread to other parts of the body) early-stage follicular lymphoma (FL) after positron emission tomography/computed tomography (PET/CT) scanning. This study concluded that radiotherapy is a highly effective treatment for these patients. Some background FL is one...
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In a nutshell This study evaluated the long-term outcomes of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone) treatment for previously untreated patients with advanced follicular lymphoma (FL). This study concluded that R-CHOP is effective in patients with newly diagnosed advanced FL. Some background FL is the second most...
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In a nutshell This study evaluated the effectiveness and safety of first-line (primary) treatment with VR-CAP (bortezomib, rituximab, cyclophosphamide, doxorubicin, prednisone) versus R-CHOP (VR-CAP with vincristine instead of bortezomib) alone in previously untreated patients with mantle cell lymphoma (MCL). This study concluded that VR-CAP was...
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In a nutshell This study evaluated the effectiveness of maintenance therapy with rituximab (Rituxan) in elderly patients with newly diagnosed follicular lymphoma (FL). This study concluded that maintenance rituximab treatment improved survival outcomes in these patients in a real-world setting. Some background Chemoimmunotherapy containing rituximab...
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In a nutshell This study evaluated the safety and effectiveness of rituximab (Rituxan) plus lenalidomide (Revlimid) for patients with previously untreated, advanced stage (stage 3 – 4) follicular lymphoma (FL). This study concluded that this regimen was similarly effective as rituximab plus chemotherapy, but had different side effects. Some...
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In a nutshell This study investigated the impact of older age on the outcomes of patients with non-Hodgkin’s lymphoma (NHL) who underwent allogeneic stem cell transplantation (alloSCT). This study concluded that alloSCT in patients older than 65 was associated with higher risks. Some background More than 60% of patients with NHL are older than...
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In a nutshell This study compared the outcomes of radioimmunotherapy versus rituximab (Rituxan) maintenance therapy in patients with follicular lymphoma (FL). This study concluded that radioimmunotherapy shows similar survival outcomes compared to rituximab maintenance therapy in patients with FL. Some background In patients with FL, rituximab...
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