In a nutshell This study aimed to compare the risk of cardiovascular incidents (CIs, side-effects) of surgical castration versus castration achieved by hormone therapy. The study concluded that CIs were higher for surgical treatment at 1.5 years after treatment, but similar thereafter. Some background For locally advanced or metastatic...
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In a nutshell This study aimed to compare abemaciclib (Verzenio) to a placebo treatment (substance with no active effect). The study concluded that it increased progression-free survival and was relatively safe to use as a first-line treatment. Some background There are several treatment options for hormone positive, HER-2 negative...
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In a nutshell This study examined accelerated partial breast irradiation (APBI) in comparison to whole breast irradiation (WBI) after surgery. They concluded that survival and long-term side-effects are the same for both treatments. However, ABPI had a higher rate of local recurrence as compared to WBI. Some background For early stage breast...
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In a nutshell This study examined whether radiotherapy treatment before surgery could improve disease-free survival, especially for patients with estrogen-receptor positive (ER+) breast cancer (dependent on the hormone estrogen for growth). This study concluded that radiotherapy before surgery improved disease-free survival. Some background For...
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In a nutshell This study aimed to investigate the effect of therapeutic care for fatigue in breast cancer patients who are undergoing chemotherapy. This study concluded that therapeutic care may decrease fatigue in breast cancer patients undergoing chemotherapy. Some background The standard of care treatment option for breast cancer and...
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In a nutshell This study examined chemoradiation (CRT) + local excision (LE) treatment for stage I/II rectal cancer patients. The study found that CRT + LE was a suitable treatment for patients with higher risk stage I disease. Some background Rectal cancer is often treated with complete removal of the tumor and...
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In a nutshell This phase 2 clinical trial will test the effectiveness of merestinib in non-small cell lung cancer patients with a mutation in the MET protein. The primary outcome will be measured by the overall response to the treatment. This study is being conducted in Boston, Massachusetts. The details Merestinib is an inhibitor of the C-Met...
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In a nutshell This phase 3 clinical trial will test the effectiveness of nivolumab (Opdivo), nivolumab with ipilimumab (Yervoy), or nivolumab with platinum-based chemotherapy compared with chemotherapy in treating patients with advanced non-small cell lung cancer (NSCLC). The primary outcome will be measured by the overall survival rate and time...
Read MoreIn a nutshell This meta-analysis aimed to establish the incidence of severe and fatal side effects associated with crizotinib (Xalkori) in patients with ALK-positive non-small-cell lung cancer (NSCLC). The authors concluded that crizotinib does not increase the risk of severe or fatal side effects compared to chemotherapy. Some background The...
Read MoreIn a nutshell The authors examined whether the lymphocyte to monocyte ratio (LMR) could predict outcome in patients with late stage EGFR positive non-small-cell lung cancer (NSCLC). They concluded LMR could be beneficial in predicting outcome for patients with EGFR positive NSCLC patients receiving first-line EGFR-TKIs. Some background Some...
Read MoreIn a nutshell The authors aimed to determine long-term quality of life (QoL) in men with prostate cancer who received cesium-131 brachytherapy. The authors concluded that there are minimal long-term changes in urinary or bowel patient-reported QoL following Cs brachytherapy. Some background Radiation therapy is a form of treatment used in...
Read MoreIn a nutshell The authors aimed to determine the effects of yoga on fatigue, erectile dysfunction, urinary problems and quality of life (QoL) in men undergoing radiation therapy for prostate cancer. The authors concluded that yoga twice-weekly during external beam radiation therapy (EBRT) significantly reduced pre-existing and radiation-related...
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