In a nutshell The study examined whether health-related quality of life (HRQoL) relates to the molecular response (MR) to tyrosine kinase inhibitors (TKIs) in patients with chronic-phase chronic myeloid leukemia (CP-CML). The authors found that improved MR had differential effects on HRQoL in such patients. Some background TKIs are a treatment used...
Read MoreCurrent disease phase-Early chronic phase Posts on Medivizor
Evaluating a method to predict the outcomes of patients with chronic myeloid leukemia treated with imatinib
In a nutshell The study tested whether the EUTOS long-term survival (ELTS) score is efficient to evaluate treatment response in patients with chronic myeloid leukemia (CML), treated with imatinib (Gleevec). The main finding was that ELTS could effectively predict treatment outcomes among such patients in the real world. Some background Initial...
Read MoreThe effects of treatment switching from imatinib to nilotinib in patients with chronic phase-chronic myeloid leukemia
In a nutshell The study investigated the effects of switching treatment to nilotinib (Tasigna) after initial therapy with imatinib (Gleevec) in patients with chronic phase of chronic myeloid leukemia (CP-CML). The authors found that switching to nilotinib after imatinib initial treatment is convenient and effective in such patients. Some background...
Read MoreWhich factors affect the safety and effectiveness of imatinib treatment for newly diagnosed chronic myeloid leukemia?
In a nutshell This study aimed to investigate the safety and effectiveness of imatinib treatment in patients with newly diagnosed chronic myeloid leukemia. This study concluded that patients of lower weight and older age are more vulnerable to side effects. Some background Imatinib (Gleevec) is a targeted therapy...
Read MoreA look at treatment responses and the possibility of stopping imatinib
In a nutshell This study examined treatment responses to imatinib (Glivec) in chronic myeloid leukemia (CML) patients. Researchers reported that about half of patients achieved an optimal response to treatment that could allow patients to safely stop therapy. Some background Molecular response (MR) is a response to treatment where hardly any or no...
Read MoreNilotinib versus dasatinib: Comparing side effects
In a nutshell This study compared side effects between two similar therapies – nilotinib (Tasigna) and dasatinib (Sprycel) – for chronic myeloid leukemia (CML). Researchers reported more serious side effects with dasatinib than with nilotinib. Some background Tyrosine kinase inhibitor (TKI) therapy is a standard first-line treatment...
Read MoreAn overview of the dose management of dasatinib
In a nutshell This study reviewed evidence on the dose management of dasatinib (Sprycel) for chronic myeloid leukemia (CML). Some background Tyrosine kinase inhibitor (TKI) therapy is a standard first-line treatment for CML. Many patients achieve optimal response to TKI therapy and have a near-normal life expectancy. However, this response is lost...
Read MoreChromosomal abnormalities at diagnosis does not predict long-term treatment outcomes with tyrosine kinase inhibitors
In a nutshell This study examined whether chromosomal abnormalities at diagnosis can predict treatment outcomes with TKIs in chronic myeloid leukemia (CML). Researchers reported similar long-term treatment outcomes in patients with and without chromosomal abnormalities at diagnosis. Some background CML is a disease in which the bone marrow makes...
Read MoreSwitching between tyrosine kinase inhibitors: 2-year follow-up of nilotinib after imatinib
In a nutshell This study examined outcomes of nilotinib (Tasigna) as a second-line therapy over 2 years in patients with chronic myeloid leukemia (CML). The results of this observational study add valuable information to the body of evidence on the effectiveness of nilotinib after imatinib in patients with chronic-phase CML. Some background...
Read MoreRemission rates after discontinuation of imatinib
In a nutshell This study examined outcomes after discontinuation of imatinib (Gleevac) in patients with chronic myeloid leukemia (CML). Researchers reported that some CML patients can safely discontinue imatinib after achieving a deep treatment response. Factors such as detectable residual leukemia cells after treatment affect the risk of losing...
Read MoreSafe to switch to imatinib for long-term use after initial treatment with nilotinib or dasatinib
In a nutshell This study examined whether switching between tyrosine kinase inhibitor (TKI) therapy is safe and effective for patients with chronic myeloid leukemia (CML). This study concluded that after achieving optimal response with a second-generation TKI such as dasatinib (Sprycel) or nilotinib (Tasigna), treatment can be safely switched to...
Read MoreModern treatment approaches for chronic-phase CML
In a nutshell This study reviewed evidence of novel agents in the treatment of chronic myeloid leukemia (CML). Some background CML is a disease in which the bone marrow makes too many mature and immature white blood cells. It is typically a slowly progressing disease that occurs mainly during or after middle age. Most patients are diagnosed in the...
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