In a nutshell This study examined whether treatment with tyrosine kinase inhibitors (TKIs) can be successfully discontinued after a failed first attempt in patients with chronic myeloid leukemia (CML). Researchers reported that a second TKI discontinuation attempt is safe and can be successful after a failed first attempt. Some background Targeted...
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The impact of imatinib on male fertility
In a nutshell This study examined whether imatinib (Gleevac) affects the fertility of men with chronic myeloid leukemia (CML). Researchers concluded that imatinib reduced sperm density, sperm count, sperm survival and activity when compared to healthy control participants. Some background CML has three phases: chronic, accelerated, and...
Read MoreWhat effect does smoking have on chronic myeloid leukemia patients?
In a nutshell This study aimed to investigate the impact of smoking on survival and progression of disease in patients with chronic myeloid leukemia. This study concluded that smoking has a negative impact on survival and progression of disease in patients with chronic myeloid leukemia. Some background Chronic myeloid leukaemia (CML)...
Read MoreIs there a benefit of reduced-intensity conditioning plus imatinib compared to imatinib alone?
In a nutshell This study examined two types of treatment regimes involving imatinib (Gleevac) for chronic myeloid leukemia (CML). Patients receiving reduced-intensity chemotherapy and a stem cell transplant before imatinib had similar outcomes to patients treated with imatinib alone. Some background Targeted therapy has become the standard...
Read MoreDasatinib in early chronic-phase chronic myeloid leukemia
In a nutshell The current study explored the use of dasatinib as an initial treatment for early chronic phase chronic myeloid leukemia (CML). The authors concluded that dasatinib was a safe and effective first-line treatment. Some background The standard first-line treatment for CML is imatinib (Gleevac). Imatinib is a tyrosine kinase inhibitor...
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