In a nutshell This study evaluated the effectiveness and safety of adding vildagliptin (Galvus, Zomelis, Jalra) to a metformin (Glucophage) and sulfonylurea (Amaryl, DiaBeta) combination in patients with type 2 diabetes. Some background Type 2 diabetes is a chronic progressive disease that occurs due to resistance to insulin. There are several...
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In a nutshell The authors evaluated the effectiveness and safety of canagliflozin for type 2 diabetes that could not be controlled with metformin therapy. Some background Metformin (Glucophage) is a recommended first-line drug therapy for type 2 diabetes that decreases glucose production in the liver, increases insulin sensitivity and enhances...
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In a nutshell In this study researchers examined the effect of a new drug, AZD1656, and its ability to control blood sugar levels in type 2 diabetic (T2D) patients. Some background Many different drugs, such as metformin (glucophage), are used to control blood sugar levels in T2D patients. However, not all patients manage to properly control their...
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In a nutshell This study evaluated whether a combination of metformin, liraglutide, and insulin detemir is a safe and effective treatment for patients with type 2 diabetes mellitus (T2DM). Some background Patients with T2DM do not produce enough insulin (or are resistant to insulin) to break down the glucose they take in from food, therefore the...
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In a nutshell This research evaluated the effect of dapagliflozin on weight loss in patients with type 2 diabetes mellitus (T2DM) uncontrolled with metformin therapy. The results showed that dapagliflozin reduced blood sugar levels by reducing patients’ weight and increasing the elimination of glucose in urine. Some background T2DM is a...
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In a nutshell This study tested the efficacy of the drug combination containing alogliptin and pioglitazone in patients with type 2 diabetes mellitus (T2DM) uncontrolled with high doses of metformin. The results showed that the combination of the two drugs was able to better control blood glucose levels than metformin alone. Some background In...
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In a nutshell This trial evaluated the effect of a smartphone-supported software called “Diabeo” on blood sugar levels in patients with poorly controlled Type 1 diabetes (T1DM). Some background People with T1DM cannot produce insulin, a hormone needed for moving glucose (a simple sugar formed from the food we eat) into body cells....
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In a nutshell The present study compared the effctiveness of two types of drugs that can be added to Metformin (Glucophage) for the treatment of poorly controlled type 2 diabetes mellitus (T2DM). Some background Type 2 diabetes mellitus affects almost 10% of all adults. Metformin (Glucophage) is the most common drug used to treat T2DM. When...
Read MoreIn a nutshell This study compared the safety and efficacy of Insulin glargine (Lantus) versus Sitagliptin (Januvia) in the management of type 2 diabetes mellitus (T2DM) poorly controlled by Metformin (Glucophage) alone. Main findings: insulin glargine provides better glycemic control than Sitagliptin when added to Metformin therapy. Some...
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In a nutshell The present study compared the effectiveness of 3 educational strategies aimed at helping patients with uncontrolled diabetes (type 1 and type 2) to achieve glycemic control (good control of blood sugar). All 3 strategies had beneficial effects on glycemic control. Most effective was an intervention based on behavioral group...
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