In a nutshell The main objectives of this study was to determine the long term effect and safety of lixisenatide (Lyxumia) as an add-on therapy in type 2 diabetes. The authors concluded that lixisenatide provided long-term blood sugar control, reduced weight and was a safe method of treatment in patients with type 2 diabetes. Some background...
Read MoreControlled (balanced) diabetes-Uncontrolled Posts on Medivizor
Switching or adding insulin to GLP-1 receptor agonists and its benefits in type 2 diabetes
In a nutshell The authors aimed to determine the benefits of adding or switching to insulin therapy in type 2 diabetes patients not responding to treatment with glucagon-like peptide-1 receptor agonists (GLP- 1RA). The authors concluded that the earlier addition of insulin was associated with better glycemic control. The authors suggest that patients...
Read MoreThe effect of liraglutide on liver fat content in patients with uncontrolled type 2 diabetes
In a nutshell The authors aimed to determine the effect of liraglutide (Victoza) on liver fat content in patients with uncontrolled type 2 diabetes. The authors concluded that six months treatment with liraglutide significantly reduced liver fat content in patients with uncontrolled type 2 diabetes by reducing body weight. Some...
Read MoreGlucagon-like peptide 1 use in patients with type 1 diabetes
In a nutshell The authors aimed to review the use of glucagon-like peptide 1 (GLP-1) agonists in patients with type 1 diabetes. The authors concluded that the use of GLP-1 agonists should be considered in patients with type 1 diabetes who are overweight or obese and not at target blood sugar control. Tolerability in patients, however, was a potential...
Read MoreCombination therapy in patients with type 2 diabetes uncontrolled by metformin
In a nutshell The authors aimed to determine the benefit of treatment with exenatide (Byetta) once weekly and dapagliflozin (Farxiga) once daily compared to exenatide or dapagliflozin alone in type 2 diabetes. The authors concluded that the combination treatment improved blood glucose control and reduced...
Read MoreCan luseogliflozin enhance control of blood glucose levels in type 2 diabetics?
In a nutshell This study examined the effects of luseogliflozin on blood glucose levels over a 24-hour period. Some background Luseogliflozin (Lusefi) is new treatment for type 2 diabetes (T2D) that prevents glucose (sugar) from being reabsorbed back into the blood from the urine and, therefore, reduces blood glucose levels....
Read MoreCombination therapy of sitagliptin and metformin is an effective and safe treatment for type 2 diabetes
In a nutshell This study investigated the effectiveness and safety of a combination therapy of sitagliptin (Januvia) and metformin (Glucophage) for type 2 diabetes patients. Some background Type 2 diabetes (T2D) is characterized by elevated blood glucose (sugar) levels. The main aim of treatment is to reduce blood glucose levels. This...
Read MoreRanolazine, a drug for chest pain, improves blood sugar levels of people with type 2 diabetes
In a nutshell This study investigated whether ranolazine was an effective and safe treatment for people with type 2 diabetes. Some background Type 2 diabetes (T2D) is characterized by elevated blood glucose (sugar) levels. Treatment involves lowering blood glucose. Patients are advised to aim for an HbA1c (average blood glucose over the past 3...
Read MoreThe impact of blood sugar levels on sleep and arterial thickness in type 2 diabetics
In a nutshell This study examined the relationship between blood sugar levels, sleep and artery thickness in type 2 diabetics. Some background Coronary heart disease (CHD) is a thickening of the wall of the arteries located in the heart. This thickening is due to a build-up of plaque, a fatty substance that attaches to the walls of the...
Read MoreA trial designed to investigate islet cell transplants in patients with “brittle” type 1 diabetes
In a nutshell This study being carried out in Illinois will evaluate the safety of islet transplants in patients with hard to control type 1 diabetes. Donor islet cells will be injected into the patients and blood glucose levels will be monitored for one year after the transplant. Success will be based on the efficacy and safety of the treatment. The...
Read MoreAvoiding insulin – GLP-1 receptor agonists can help control glucose levels
In a nutshell This study compared the effectiveness of albiglutide, a glucagon-like peptide-1 receptor agonist, with insulin glargine in type 2 diabetes mellitus. Some background Type 2 diabetes mellitus is a progressive disease, which means patients will need to alter or increase treatments over time. While type 2 diabetes is often initially...
Read MoreUncontrolled diabetes? Try adding metformin to your acarbose!
In a nutshell The authors aimed to compare the effectiveness and safety of acarbose (Precose) used with or without metformin (Glucophage) in patients with type 2 diabetes. Some background Type 2 diabetes is a long-term progressive disease that occurs due to resistance to insulin which causes high blood glucose...
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