In a nutshell This study investigated the effectiveness of hyperthermic intraperitoneal chemotherapy (HIPEC) in colorectal cancer patients with early stage peritoneal metastasis (PM; when the cancer spreads to the abdominal lining). Researchers suggested that HIPEC may benefit these patients. Some background The peritoneal region is the second...
Read MoreIn a nutshell This study investigated the association between malnutrition caused by pre-surgery chemotherapy and radiation (CRT) and rectal cancer treatment tolerance and anastomotic leakage (AL; leakage of intestinal fluids). Researchers reported that malnutrition related to CRT is associated with treatment tolerance and AL. Some background CRT...
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In a nutshell This study investigated the effect of chemotherapy drug dose on the survival outcomes of stage 3 colon cancer patients. Some background Relative dose intensity (RDI) refers to the proportion of the standard drug dose received during chemotherapy. Previous studies have shown that an RDI greater than 70% is associated with better...
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In a nutshell This study investigated whether cancer that has spread to the peritoneal surface (the lining of the abdominal cavity) can be treated as effectively as cancer that has spread to the liver in colorectal cancer patients. Some background The liver is the most common metastatic site (site for the cancer to...
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In a nutshell The aim of this study was to evaluate the impact of primary tumor removal and lymph node dissection on disease outcome in metastatic colorectal cancer. Some background Approximately 15-20% of patients with colorectal cancer are diagnosed with distant metastasis (spread of the cancer) despite widespread screening. While in some...
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In a nutshell The current study examined whether the proteins versican and lumican were predictive of prognosis among colon cancer patients. Some background Colon cancer treatments vary depending on the type and stage of the disease. Patients with advanced cancer, which has invaded the surrounding lymph nodes, usually receive chemotherapy along...
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In a nutshell This study evaluated p300 as a potential prognostic marker for colorectal cancer survival. Some background Survival of colorectal cancer patients is currently estimated according to cancer staging and lymph node involvement. However, both survival and the response to treatments vary widely between patients. Therefore, new molecules...
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In a nutshell This study estimated survival gain with the addition of aflibercept (Zaltrap) to standard chemotherapy among patients with metastatic colorectal cancer. Some background A combination chemotherapy regimen referred to as FOLFIRI (folinic acid, 5-fluorouracil and irinotecan) is considered the standard of care in the treatment of...
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In a nutshell This study evaluated the use of capecitabine in combination with bevacizumab (Avastin) in the treatment of unresectable metastatic colorectal cancer. Some background Current treatment of unresectable metastatic colorectal cancer (wide spread cancer that cannot be removed by surgery do to size or location) includes chemotherapy, such...
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In a nutshell This study examined whether there is an increased risk of hypertension among cancer patients being treated with regorafenib (Stivarga). Some background Vascular endothelial growth factor receptors (VEGF-r) are complexes on the surface of cells which stimulate the growth of new blood vessels, and are crucial for cancer growth and...
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In a nutshell This study examined the effectiveness and safety of a new chemotherapy combination including oxaliplatin, irinotecan, and S-1 for the treatment of metastatic colorectal cancer. Some background For several years, standard chemotherapy for metastatic colorectal cancer (a cancer which has spread to other organs) included a combination...
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In a nutshell This study examined whether fatty liver disease protects colorectal cancer patients from developing liver metastasis. Some background Colorectal cancer (CRC) is most likely to metastasize (spread) to the liver. Liver metastasis accounts for 50% of all cases of metastatic colorectal cancer. Since very limited treatments are...
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