In a nutshell This review analyzed the safety and effectivity of flexibly timed insulin degludec treatment among both type I and type II diabetic patients. Some background Insulin therapy is often needed to restore normal blood glucose levels in both type I and type II diabetic patients. However, the rigid injection schedule necessary and the fear...
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In a nutshell This review assessed the development and use of an artificial pancreas (a bi-hormonal closed loop system) in the management of type 1 diabetes mellitus. Some background A normally functioning pancreas releases both insulin and the hormone glucagon. Glucagon acts in opposition to insulin, raising blood glucose levels when they become...
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In a nutshell This study evaluated the effects of insulin jet-injections on insulin and glucose blood levels after a meal. Some background Daily insulin injections are a routine part of life for millions of diabetic patients. In an attempt to reduce patient discomfort, jet-injectors were developed to allow the delivery of insulin without the use...
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In a nutshell This article reviewed the risks and benefits of SGLT2 inhibitors such as dapagliflozin (Forxiga) and canagliflozin (Invokana) in the treatment of type 2 diabetes mellitus (T2DM). Some background SGLT2 inhibitors are a newly developed class of anti-diabetes drugs that cause more glucose to be eliminated from the blood...
Read MoreIn a nutshell This review explored whether strict glycemic control can reduce the risk of cardiovascular events among diabetic patients. Some background Hyperglycemia, or high blood glucose levels, can damage both large and small blood vessels. Damage to large blood vessels significantly elevates the risk for complications such as heart attacks or...
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In a nutshell This trial compared the effectiveness of three insulin regimens for the treatment of uncontrolled type 2 diabetes. Some background Many type 2 diabetic patients begin insulin treatment when other methods of controlling blood glucose levels fail. Several insulin drugs and combinations may be used in the treatment of diabetes. Most...
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In a nutshell This review analyzed the effects of incretin based therapies in combination with insulin as treatment for uncontrolled type 2 diabetes mellitus (T2DM). Some background Non-insulin oral drugs, such as incretin based therapies, are a common treatment for T2DM patients. Incretins are hormones that are normally released by the body in...
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In a nutshell This study aimed at predicting which diabetic patients are at risk for developing hypoglycemia with insulin therapy. Some background Patients with type 2 diabetes mellitus (T2DM) cannot regulate their blood glucose levels, leading to a build-up of glucose in the bloodstream. Lifestyle changes, such as diet and exercise, along with...
Read MoreIn a nutshell In this study researchers examined two types of insulin; insulin degludec (triseba; IDeg) and insulin glargine (lantus; IGlar). This study compared the quality of life (QOL) as reported by patients between users of these two drugs. Some background Insulin is often used to manage blood sugar levels in diabetic patients. However,...
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In a nutshell This study evaluated the efficacy and safety of the glutamic acid decarboxylase (GAD) vaccine for the treatment of newly diagnosed patients with type 1 diabetes mellitus (T1DM). Some background T1DM results from an autoimmune (an immune response against the body's own cells and tissues) destruction of insulin-producing...
Read MoreIn a nutshell This study compared the risk of severe hypoglycemia (an abnormally low blood sugar level) between patients with type 1 diabetes mellitus (T1DM) taking human insulin and synthetic insulin substitutes (insulin analogues). Some background Patients with T1DM do not produce insulin from the pancreas. Therefore, in order to use blood...
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In a nutshell This study looks at children with newly diagnosed Type 1 diabetes. It asks whether Vitamin D supplements help their bodies maintain some insulin production. In children with low Vitamin D levels, the study seems to show that Vitamin D supplements do help maintain insulin production. Some background Type 1 diabetes (formerly...
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